B. DNA binding properties C. PPAR ligand-binding properties D. Alternative pathways for
PPAR activation E. PPAR-mediated transactivation properties III. Physiological Aspects A …

Blood clotting involves a multitude of proteins that act in concert in response to vascular
injury to produce the procoagulant enzyme α-thrombin, which in turn is responsible for the …

Thrombosis is a major cause of morbidity and mortality in cancer patients. The pathogenesis
of blood coagulation activation in oncological patients is complex and involves both clinical …

Blood coagulation factor VII (fVII) is physiologically synthesized in the liver and released into
the blood. Binding of fVII to tissue factor (TF) at sites of vascular injury triggers coagulation …

The hepatocyte nuclear factor 4 (HNF-4) is a member of the nuclear receptor superfamily
and participates in the regulation of several genes involved in diverse metabolic pathways …

Recent studies have provided evidence for associations between common polymorphic
markers in the coagulation factor VII (FVII) gene and plasma FVII levels. Here we describe …

Background Plasma factor VII concentrations (FVIIa), a marker of coronary artery disease
(CAD) risk, are influenced by genetic markers at the promoter site: the A2 allele, due to a …

Upon vascular injury, activation of factor VII is effected by tissue factor (TD and this reaction
is the primary event in blood coagulation. The TF: FYIIa complex serves to activate factors IX …

The functional mapping of the human cytochrome P4502D6 (CYP2D6) promoter in HepG2
cells revealed the presence of both positive and negative regulatory elements. One of these …

Tissue factor (TF) is an integral membrane protein widely expressed in normal human cells.
Blood coagulation factor VII (fVII) is a key enzyme in the extrinsic coagulation cascade that is …