Cancer-associated neurogenesis and nerve-cancer cross-talk

DA Silverman, VK Martinez, PM Dougherty, JN Myers… - Cancer research, 2021 - AACR
In this review, we highlight recent discoveries regarding mechanisms contributing to nerve-
cancer cross-talk and the effects of nerve-cancer cross-talk on tumor progression and …

Androgen receptor signaling in prostate cancer and therapeutic strategies

A Jacob, R Raj, DB Allison, ZW Myint - Cancers, 2021 - mdpi.com
Simple Summary Early-stage and castration-sensitive prostate cancer (PCa) growth is solely
mediated by androgen signaling pathways. AR signaling inhibitors (ARSIs) have …

Androgen receptor-dependent mechanisms mediating drug resistance in prostate cancer

M Ehsani, FO David, A Baniahmad - Cancers, 2021 - mdpi.com
Simple Summary Prostate cancer can develop under hormone treatment and chemotherapy
from a castration-sensitive towards a castration-resistant into a drug resistant-tumor. The …

Androgens induce invasiveness of triple negative breast cancer cells through AR/Src/PI3-K complex assembly

P Giovannelli, M Di Donato, F Auricchio, G Castoria… - Scientific Reports, 2019 - nature.com
Breast cancer (BC) is still characterized by high morbidity and mortality. A specific BC
subtype named triple negative BC (TNBC) lacks estrogen and progesterone receptors (ER …

Estrogens and their receptors in prostate cancer: therapeutic implications

E Di Zazzo, G Galasso, P Giovannelli… - Frontiers in …, 2018 - frontiersin.org
A major challenge in clinical management of prostate cancer (PC) is to limit tumor growth
and prevent metastatic spreading. Considerable efforts have been made to discover new …

The androgen receptor/filamin A complex as a target in prostate cancer microenvironment

M Di Donato, A Zamagni, G Galasso, E Di Zazzo… - Cell Death & …, 2021 - nature.com
Prostate cancer represents the major cause of cancer-related death in men and patients
frequently develop drug-resistance and metastatic disease. Most studies focus on hormone …

The nerve growth factor-delivered signals in prostate cancer and its associated microenvironment: When the dialogue replaces the monologue

M Di Donato, P Giovannelli, A Migliaccio, G Castoria - Cell & Bioscience, 2023 - Springer
Prostate cancer (PC) represents the most diagnosed and the second most lethal cancer in
men worldwide. Its development and progression occur in concert with alterations in the …

Three-dimensional cell cultures as an in vitro tool for prostate cancer modeling and drug discovery

F Fontana, M Raimondi, M Marzagalli… - International journal of …, 2020 - mdpi.com
In the last decade, three-dimensional (3D) cell culture technology has gained a lot of interest
due to its ability to better recapitulate the in vivo organization and microenvironment of in …

Biomarkers that differentiate benign prostatic hyperplasia from prostate cancer: A literature review

CJ McNally, MW Ruddock, T Moore… - Cancer management …, 2020 - Taylor & Francis
Prediction of prostate cancer in primary care is typically based upon serum total prostate-
specific antigen (tPSA) and digital rectal examination results. However, these tests lack …

Nerve growth factor induces proliferation and aggressiveness in prostate cancer cells

M Di Donato, G Cernera, A Migliaccio, G Castoria - Cancers, 2019 - mdpi.com
Resistance to hormone therapy and disease progression is the major challenge in clinical
management of prostate cancer (PC). Drugs currently used in PC therapy initially show a …