Mitochondrial oxidative stress—a causative factor and therapeutic target in many diseases

P Kowalczyk, D Sulejczak, P Kleczkowska… - International journal of …, 2021 - mdpi.com
The excessive formation of reactive oxygen species (ROS) and impairment of defensive
antioxidant systems leads to a condition known as oxidative stress. The main source of free …

Mitochondria as a therapeutic target for common pathologies

MP Murphy, RC Hartley - Nature Reviews Drug Discovery, 2018 - nature.com
Although the development of mitochondrial therapies has largely focused on diseases
caused by mutations in mitochondrial DNA or in nuclear genes encoding mitochondrial …

A comprehensive review on the emerging role of long non-coding RNAs in the regulation of NF-κB signaling in inflammatory lung diseases

AA Bhat, O Afzal, N Agrawal, R Thapa… - International journal of …, 2023 - Elsevier
Public health globally faces significant risks from conditions like acute respiratory distress
syndrome (ARDS), chronic obstructive pulmonary disease (COPD), and various …

Mitochondrial dynamics and mitophagy in lung disorders

A Sharma, S Ahmad, T Ahmad, S Ali, MA Syed - Life sciences, 2021 - Elsevier
Mitochondria are biosynthetic, bioenergetic, and signaling organelles which are critical for
physiological adaptations and cellular stress responses to the environment. Various …

Exogenous melatonin maintains leaf quality of postharvest Chinese flowering cabbage by modulating respiratory metabolism and energy status

X Tan, Z Fan, Z Zeng, W Shan, J Kuang, W Lu… - Postharvest Biology and …, 2021 - Elsevier
The efficacy of melatonin on postharvest quality of Chinese flowering cabbage was
investigated in this study. Treatment of Chinese cabbage with melatonin significantly …

iNOS as a metabolic enzyme under stress conditions

S Anavi, O Tirosh - Free Radical Biology and Medicine, 2020 - Elsevier
Nitric oxide (NO) is a free radical acting as a cellular signaling molecule in many different
biochemical processes. NO is synthesized from l-arginine through the action of the nitric …

Cellular senescence in aging lungs and diseases

A Aghali, ML Koloko Ngassie, CM Pabelick… - Cells, 2022 - mdpi.com
Cellular senescence represents a state of irreversible cell cycle arrest occurring naturally or
in response to exogenous stressors. Following the initial arrest, progressive phenotypic …

The essential functions of mitochondrial dynamics in immune cells

JH Xie, YY Li, J Jin - Cellular & molecular immunology, 2020 - nature.com
Mitochondria are highly mobile organelles due to fission, fusion, transport, and mitophagy,
and these processes are known as mitochondrial dynamics. Mitochondrial dynamics play an …

Mitochondrial dysfunction in chronic respiratory diseases: implications for the pathogenesis and potential therapeutics

W Zhou, J Qu, S Xie, Y Sun… - Oxidative Medicine and …, 2021 - Wiley Online Library
Mitochondria are indispensable for energy metabolism and cell signaling. Mitochondrial
homeostasis is sustained with stabilization of mitochondrial membrane potential, balance of …

The pathophysiological role of mitochondrial oxidative stress in lung diseases

X Liu, Z Chen - Journal of Translational Medicine, 2017 - Springer
Mitochondria are critically involved in reactive oxygen species (ROS)-dependent lung
diseases, such as lung fibrosis, asbestos, chronic airway diseases and lung cancer …