The brain harbors a unique ability to, figuratively speaking, shift its gears. During
wakefulness, the brain is geared fully toward processing information and behaving, while …

In the past decade, evidence for a fluid clearance pathway in the central nervous system
known as the glymphatic system has grown. According to the glymphatic system concept …

The emerging interest in brain fluid transport has prompted a need for techniques that
provide an understanding of what factors regulate cerebrospinal fluid (CSF) production …

OBJECTIVE Diffusion tensor imaging (DTI) along the perivascular space (ALPS)(DTI-ALPS)—
by calculating the ALPS index, a ratio accentuating water diffusion in the perivascular space …

Glymphatic fluid transport eliminates metabolic waste from the brain including amyloid-β, yet
the methodology for studying efflux remains rudimentary. Here, we develop a method to …

Sleep is an essential physiological function that sustains human life. Sleep disorders involve
problems with the quality, duration, and abnormal behaviour of sleep. Insomnia is the most …

Remarkable progress made in the past few decades in brain research enables the
manipulation of neuronal activity in single neurons and neural circuits and thus allows the …

Assessing glymphatic function using in-vivo imaging method is of great value for
understanding its contribution to major brain diseases. In the present study, we aim to …

The glymphatic system is a brain-wide waste drainage system that promotes cerebrospinal
fluid circulation through the brain to remove waste metabolites. Currently, the most common …

Advanced age, accompanied by impaired glymphatic function, is a key risk factor for many
neurodegenerative diseases. To study age-related differences in the human glymphatic …