Mediators of neuropathic pain; focus on spinal microglia, CSF-1, BDNF, CCL21, TNF-α, Wnt ligands, and interleukin 1β
Intractable neuropathic pain is a frequent consequence of nerve injury or disease. When
peripheral nerves are injured, damaged axons undergo Wallerian degeneration. Schwann …
peripheral nerves are injured, damaged axons undergo Wallerian degeneration. Schwann …
Clinical management of pain in rodents
PL Foley, LV Kendall, PV Turner - Comparative Medicine, 2019 - ingentaconnect.com
The use of effective regimens for mitigating pain remain underutilized in research rodents
despite the general acceptance of both the ethical imperative and regulatory requirements …
despite the general acceptance of both the ethical imperative and regulatory requirements …
K+ Channels in Primary Afferents and Their Role in Nerve Injury-Induced Pain
PA Smith - Frontiers in Cellular Neuroscience, 2020 - frontiersin.org
Sensory abnormalities generated by nerve injury, peripheral neuropathy or disease are
often expressed as neuropathic pain. This type of pain is frequently resistant to therapeutic …
often expressed as neuropathic pain. This type of pain is frequently resistant to therapeutic …
Methods for evaluating gait associated dynamic balance and coordination in rodents
AD Modi, A Parekh, ZH Patel - Behavioural Brain Research, 2023 - Elsevier
Balance is the dynamic and unconscious control of the body's centre of mass to maintain
postural equilibrium. Regulated by the vestibular system, head movement and acceleration …
postural equilibrium. Regulated by the vestibular system, head movement and acceleration …
Neuropathic pain; what we know and what we should do about it
PA Smith - Frontiers in Pain Research, 2023 - frontiersin.org
Neuropathic pain can result from injury to, or disease of the nervous system. It is notoriously
difficult to treat. Peripheral nerve injury promotes Schwann cell activation and invasion of …
difficult to treat. Peripheral nerve injury promotes Schwann cell activation and invasion of …
Pain in the Ehlers–Danlos syndromes: Mechanisms, models, and challenges
Chronic pain is one of the most common, yet poorly studied, complaints in people suffering
from Ehlers–Danlos syndromes (EDS). This heterogeneous group of heritable connective …
from Ehlers–Danlos syndromes (EDS). This heterogeneous group of heritable connective …
Tmem160 contributes to the establishment of discrete nerve injury-induced pain behaviors in male mice
D Segelcke, HK Fischer, M Hütte, S Dennerlein… - Cell Reports, 2021 - cell.com
Chronic pain is a prevalent medical problem, and its molecular basis remains poorly
understood. Here, we demonstrate the significance of the transmembrane protein (Tmem) …
understood. Here, we demonstrate the significance of the transmembrane protein (Tmem) …
Evaluating pain behaviours: Widely used mechanical and thermal methods in rodents
AD Modi, A Parekh, YN Pancholi - Behavioural Brain Research, 2023 - Elsevier
Globally, over 300 million surgical procedures are performed annually, with pain being one
of the most common post-operative side effects. During the onset of injury, acute pain plays …
of the most common post-operative side effects. During the onset of injury, acute pain plays …
Grimace scores: tools to support the identification of pain in mammals used in research
S Cohen, T Beths - Animals, 2020 - mdpi.com
Simple Summary The ability to identify and assess pain is paramount in animal research to
address the 'refinement'principle of the 3Rs (Reduction, Refinement, Replacement), satisfy …
address the 'refinement'principle of the 3Rs (Reduction, Refinement, Replacement), satisfy …
NET-triggered NLRP3 activation and IL18 release drive oxaliplatin-induced peripheral neuropathy
T Lin, L Hu, F Hu, K Li, CY Wang, LJ Zong… - Cancer immunology …, 2022 - AACR
Oxaliplatin is an antineoplastic agent frequently used in the treatment of gastrointestinal
tumors. However, it causes dose-limiting sensorimotor neuropathy, referred to as oxaliplatin …
tumors. However, it causes dose-limiting sensorimotor neuropathy, referred to as oxaliplatin …