Intractable neuropathic pain is a frequent consequence of nerve injury or disease. When
peripheral nerves are injured, damaged axons undergo Wallerian degeneration. Schwann …

The use of effective regimens for mitigating pain remain underutilized in research rodents
despite the general acceptance of both the ethical imperative and regulatory requirements …

Sensory abnormalities generated by nerve injury, peripheral neuropathy or disease are
often expressed as neuropathic pain. This type of pain is frequently resistant to therapeutic …

Balance is the dynamic and unconscious control of the body's centre of mass to maintain
postural equilibrium. Regulated by the vestibular system, head movement and acceleration …

Neuropathic pain can result from injury to, or disease of the nervous system. It is notoriously
difficult to treat. Peripheral nerve injury promotes Schwann cell activation and invasion of …

Chronic pain is one of the most common, yet poorly studied, complaints in people suffering
from Ehlers–Danlos syndromes (EDS). This heterogeneous group of heritable connective …

Chronic pain is a prevalent medical problem, and its molecular basis remains poorly
understood. Here, we demonstrate the significance of the transmembrane protein (Tmem) …

Globally, over 300 million surgical procedures are performed annually, with pain being one
of the most common post-operative side effects. During the onset of injury, acute pain plays …

Simple Summary The ability to identify and assess pain is paramount in animal research to
address the 'refinement'principle of the 3Rs (Reduction, Refinement, Replacement), satisfy …

Oxaliplatin is an antineoplastic agent frequently used in the treatment of gastrointestinal
tumors. However, it causes dose-limiting sensorimotor neuropathy, referred to as oxaliplatin …