Real-time investigation of cerebral blood flow (CBF), and oxy-and deoxyhemoglobin
concentration (HbO, HbR) dynamics has been difficult until recently due to limited spatial …

We introduce and validate a pressure measurement paradigm that reduces extracerebral
contamination from superficial tissues in optical monitoring of cerebral blood flow with …

Signal increases in functional magnetic resonance imaging (fMRI) are believed to be a
result of decreased paramagnetic deoxygenated haemoglobin (deoxyHb) content in the …

Wide-field calcium imaging is often used to measure brain dynamics in behaving mice. With
a large field of view and a high sampling rate, wide-field imaging can monitor activity from …

In functional brain imaging there is controversy over which hemodynamic signal best
represents neural activity. Intrinsic signal optical imaging (ISOI) suggests that the best signal …

Using light, we are able to visualize the hemodynamic behavior of the brain to better
understand neurovascular coupling and cerebral metabolism. In vivo optical imaging of …

Using optical methods through a closed cranial window over the rat primary sensory cortex
in chloralose/urethane-anesthetized rats we evaluated the time course of oxygen delivery …

Animal models of stroke are used extensively to study the mechanisms involved in the acute
and chronic phases of recovery following stroke. A translatable animal model that closely …

By means of noninvasive near-infrared spectroscopy (NIRS), cerebral concentration
changes in oxygenated and deoxygenated hemoglobin ([oxy-Hb] and [deoxy-Hb]) can be …

These are exciting times for the field of optical imaging of brain function. Rapid
developments in theory and technology continue to considerably advance understanding of …