Executive function is an umbrella term that includes cognitive processes such as decision-
making, impulse control, attention, behavioral flexibility, and working memory. Each of these …

Increasing evidence suggests a role of neuroinflammation in substance use disorders
(SUDs). This Review presents findings from neuroimaging studies assessing brain markers …

Background and aims Pioglitazone (PIO), a potent agonist of PPAR‐gamma, is a promising
candidate treatment for cocaine use disorder (CUD). We tested the effects of PIO on targeted …

Background Similarities between behavioral and substance addictions exist. However,
direct neurobiological comparison between addictive disorders is rare. Determination of …

Traumatic brain injury (TBI) has been linked to the development of numerous psychiatric
diseases, including substance use disorder. However, it can be difficult to ascertain from …

Cocaine dependence has been associated with deficits in white matter (WM) integrity.
Nevertheless, what happens to WM integrity after long-term abstinence is not fully …

Sensitization is a basic property of the nervous system whereby repeated exposure to a
stimulus results in an increase in responding to that stimulus. This increase in responding …

Objective: Chronic substance use and its effects on brain function and structure has long
been of interest to clinicians and researchers. Prior cross-sectional comparisons of diffusion …

Cocaine dependence (CD) is associated with several cognitive deficits. Accumulating
evidence, based on human and animal studies, has led to models for interpreting the neural …

Background Previous diffusion tensor imaging (DTI) studies have consistently shown that
subjects with cocaine use disorder (CocUD) had altered white matter microstructure in the …