Protein kinases represent a very pharmacologically attractive class of targets; however,
some members of the family still remain rather unexplored. The biology and therapeutic …

The Janus kinase (JAK) signal transducer and activator of transcription (JAK-STAT) pathway
is an evolutionarily conserved mechanism of transmembrane signal transduction that …

Mutations in kinases are abundant and critical to study signaling pathways and regulatory
roles in human disease, especially in cancer. Somatic mutations in kinase genes can affect …

Purpose Recently, long noncoding RNA LINC01134 has been shown to reduce cell viability
and apoptosis via the antioxidant stress pathway, thereby enhancing OXA resistance in …

Cancer, a noncommunicable disease, is the leading cause of mortality worldwide and is
anticipated to rise by 75% in the next two decades, reaching approximately 25 million cases …

The anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase known for its oncogenic
potential that is involved in the development of the peripheral and central nervous system …

Numerous protein kinases encoded in the genome have become attractive targets for the
treatment of different types of cancer. As of January 2020, a total of 52 small-molecule …

The discovery of the phosphatidylinositol 3-kinase (PI 3-kinase) pathway was a major
advance in understanding eukaryotic signal transduction. The high frequency of PI 3-kinase …

Simple Summary Anti-angiogenic therapies targeting the vascular endothelial growth factor
(VEGF) signaling are established in the arsenal of cancer treatments. Despite the …

Tyrosine phosphorylation (pTyr), much of which occurred on localized multiple sites, initiates
cellular signaling, governs cellular functions, and its dysregulation is implicated in many …