Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal form of cancer characterized by
drug resistance, urging new therapeutic strategies. In recent years, protein kinases have …

Tyrosine kinase inhibitor (TKI) is a standard treatment for patients with NSCLC harboring
constitutively active epidermal growth factor receptor (EGFR) mutations. However, most rare …

Multiple Sclerosis (MS) is a chronic inflammatory disease of the central nervous system
(CNS) leading to demyelination and neurodegeneration. Although its etiology is not fully …

In this study, we designed and synthesized a number of novel pyrido [2, 3-d] pyrimidine-
thiazolidine-1, 2, 3-triazole derivatives and investigated them in vitro for their inhibitory …

Epidermal growth factor receptor (EGFR) is an integral surface protein mediating cellular
response to a number of growth factors. Its overexpression and increased activation due to …

Pyrazolo [3, 4-d] pyrimidines have become of significant interest for the medicinal chemistry
community as a privileged scaffold for the development of kinase inhibitors to treat a range …

Glucocorticoids are widely used as an ophthalmic medication. A common, sight-threatening
adverse event of glucocorticoid usage is ocular hypertension, caused by dysfunction of the …

Introduction: Angiogenesis is a vital process for cellular functions in both physiological and
pathophysiological conditions and is one of the hallmarks of cancer progression and …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder that causes the
progressive loss of motoneurons and, unfortunately, there is no effective treatment for this …

Parallel reaction monitoring (PRM) has emerged as a popular approach for targeted protein
quantification. With high ion utilization efficiency and first-in-class acquisition speed, the …