To combat multifactorial refractory diseases, such as cancer, cardiovascular, and
neurodegenerative diseases, multitarget drugs have become an emerging area of research …

The quinoline ring system has long been known as a versatile nucleus in the design and
synthesis of biologically active compounds. Currently, more than one hundred quinoline …

Abstract Targeted Protein Modification (TPM) is an umbrella term encompassing numerous
tools and approaches that use bifunctional agents to induce a desired modification over the …

Kinase drug selectivity is the ground challenge in cancer research. Due to the structurally
similar kinase drug pockets, off-target inhibitor toxicity has been a major cause for clinical …

Antimalarial drug discovery has until recently been driven by high‐throughput phenotypic
cellular screening, allowing millions of compounds to be assayed and delivering clinical …

Surveillance pouchoscopy is recommended for patients with restorative proctocolectomy
with ileal pouch–anal anastomosis in ulcerative colitis or familial adenomatous polyposis …

Janus kinase (JAK) inhibitors are used to treat rheumatoid arthritis (RA). We assessed the
effects of tofacitinib on bone density and bone markers in association with clinical and …

In multiple sclerosis (MS) persisting disability can derive from acute relapses or,
alternatively, from slow and steady deterioration, termed chronic progression. Emerging data …

Heterocyclic compounds are that type of substances that are deeply intertwined with
biological processes. Heterocycles are found in about 90% of commercially available …

Drug repurposing aims to find new uses for already existing and approved drugs. We now
provide a brief overview of recent developments in drug repurposing using machine …