The endoplasmic reticulum (ER) chaperone BiP is a master regulator of ER functions: Getting by with a little help from ERdj friends
The endoplasmic reticulum (ER) represents the entry point into the secretory pathway where
nascent proteins encounter a specialized environment for their folding and maturation …
nascent proteins encounter a specialized environment for their folding and maturation …
An update on Sec61 channel functions, mechanisms, and related diseases
The membrane of the endoplasmic reticulum (ER) of nucleated human cells harbors the
protein translocon, which facilitates membrane integration or translocation of almost every …
protein translocon, which facilitates membrane integration or translocation of almost every …
A translocation pathway for vesicle-mediated unconventional protein secretion
Many cytosolic proteins lacking a signal peptide, called leaderless cargoes, are secreted
through unconventional secretion. Vesicle trafficking is a major pathway involved. It is …
through unconventional secretion. Vesicle trafficking is a major pathway involved. It is …
Quantitative subcellular reconstruction reveals a lipid mediated inter-organelle biogenesis network
RG Lee, DL Rudler, SA Raven, L Peng, A Chopin… - Nature Cell …, 2024 - nature.com
The structures and functions of organelles in cells depend on each other but have not been
systematically explored. We established stable knockout cell lines of peroxisomal, Golgi and …
systematically explored. We established stable knockout cell lines of peroxisomal, Golgi and …
Translocon component Sec62 acts in endoplasmic reticulum turnover during stress recovery
F Fumagalli, J Noack, TJ Bergmann, E Cebollero… - Nature cell …, 2016 - nature.com
The endoplasmic reticulum (ER) is a site of protein biogenesis in eukaryotic cells. Perturbing
ER homeostasis activates stress programs collectively called the unfolded protein response …
ER homeostasis activates stress programs collectively called the unfolded protein response …
Let's talk about Secs: Sec61, Sec62 and Sec63 in signal transduction, oncology and personalized medicine
M Linxweiler, B Schick, R Zimmermann - Signal transduction and …, 2017 - nature.com
The heterotrimeric Sec61 complex and the dimeric Sec62/Sec63 complex are located in the
membrane of the human endoplasmic reticulum (ER) and play a central role in translocation …
membrane of the human endoplasmic reticulum (ER) and play a central role in translocation …
[HTML][HTML] Co-translational targeting and translocation of proteins to the endoplasmic reticulum
Co-translational protein targeting to the endoplasmic reticulum (ER), represents an
evolutionary-conserved mechanism to target proteins into the secretory pathway. In this …
evolutionary-conserved mechanism to target proteins into the secretory pathway. In this …
[HTML][HTML] A network of cytosolic factors targets SRP-independent proteins to the endoplasmic reticulum
T Ast, G Cohen, M Schuldiner - Cell, 2013 - cell.com
Translocation into the endoplasmic reticulum (ER) is an initial and crucial biogenesis step
for all secreted and endomembrane proteins in eukaryotes. ER insertion can take place …
for all secreted and endomembrane proteins in eukaryotes. ER insertion can take place …
A clearer picture of the ER translocon complex
M Gemmer, F Förster - Journal of cell science, 2020 - journals.biologists.com
The endoplasmic reticulum (ER) translocon complex is the main gate into the secretory
pathway, facilitating the translocation of nascent peptides into the ER lumen or their …
pathway, facilitating the translocation of nascent peptides into the ER lumen or their …
The Sec translocon mediated protein transport in prokaryotes and eukaryotes
K Denks, A Vogt, I Sachelaru, NA Petriman… - Molecular membrane …, 2014 - Taylor & Francis
Protein transport via the Sec translocon represents an evolutionary conserved mechanism
for delivering cytosolically-synthesized proteins to extra-cytosolic compartments. The Sec …
for delivering cytosolically-synthesized proteins to extra-cytosolic compartments. The Sec …