[HTML][HTML] Rapamycin improves Graves' orbitopathy by suppressing CD4+ cytotoxic T lymphocytes

M Zhang, KKL Chong, Z Chen, H Guo, Y Liu, Y Kang… - JCI insight, 2023 - ncbi.nlm.nih.gov
CD4+ cytotoxic T lymphocytes (CTLs) were recently implicated in immune-mediated
inflammation and fibrosis progression of Graves' orbitopathy (GO). However, little is known …

Graves disease: latest understanding of pathogenesis and treatment options

G Lanzolla, M Marinò, F Menconi - Nature Reviews Endocrinology, 2024 - nature.com
Graves disease is the most common cause of hyperthyroidism in iodine-sufficient areas. The
main responsible mechanism is related to autoantibodies that bind and activate the …

Sirolimus as a second-line treatment for Graves' orbitopathy

G Lanzolla, MN Maglionico, S Comi, F Menconi… - Journal of …, 2022 - Springer
Objectives A beneficial effect of sirolimus in Graves' orbitopathy (GO) was reported,
suggesting a possible use in clinical practice. We conducted an observational, single-centre …

Long-term outcome of Graves' orbitopathy following treatment with sirolimus

S Comi, G Cosentino, G Lanzolla, F Menconi… - Journal of …, 2024 - Springer
Objectives Sirolimus was found to be associated with a better outcome of Graves'
orbitopathy (GO) at 24 weeks compared to methylprednisolone. We conducted a …

Aktuelle Therapieansätze der endokrinen Orbitopathie–sind die zielgerichteten Therapien die Zukunft?

A Eckstein, M Stöhr, GE Görtz, A Gulbins… - Klinische …, 2024 - thieme-connect.com
Gravesʼ orbitopathy is an autoimmune disease of the orbit that most frequently occurs with
Gravesʼ hyperthyroidism. The occurrence of autoantibodies directed against the TSH …

Cosmetic Surgery for Thyroid-Associated Orbitopathy

JCP Roos, R Murthy, D Surace - Oculoplastic, Lacrimal and Orbital …, 2024 - Springer
Abstract Ophthalmologists generally consider Thyroid Associated Orbitopathy (TAO) to be a
self-limiting periocular autoimmune condition often resulting in diplopia and which can …

[引用][C] Sirolimus versus mycophenolate mofetil for triple immunosuppression in thyroid eye disease patients with recent‐onset intractable diplopia: A prospective …

KKH Lai, Y Wang, CP Pang… - Clinical & Experimental …, 2023 - Wiley Online Library
Thyroid eye disease (TED) is the most common extrathyroidal manifestation of autoimmune
thyroid disease (AITD), which typically runs a biphasic course that begins with progressive …