[HTML][HTML] Emerging roles and the regulation of aerobic glycolysis in hepatocellular carcinoma

J Feng, J Li, L Wu, Q Yu, J Ji, J Wu, W Dai… - Journal of Experimental & …, 2020 - Springer
Liver cancer has become the sixth most diagnosed cancer and the fourth leading cause of
cancer death worldwide. Hepatocellular carcinoma (HCC) is responsible for up to 75–85 …

Biology and significance of alpha‐fetoprotein in hepatocellular carcinoma

PR Galle, F Foerster, M Kudo, SL Chan… - Liver …, 2019 - Wiley Online Library
Hepatocellular carcinoma (HCC) is one of the most common causes of cancer‐related
deaths globally due, in part, to the majority of patients being diagnosed with intermediate or …

[HTML][HTML] N6-methyladenosine-modified CircRNA-SORE sustains sorafenib resistance in hepatocellular carcinoma by regulating β-catenin signaling

J Xu, Z Wan, M Tang, Z Lin, S Jiang, L Ji, K Gorshkov… - Molecular cancer, 2020 - Springer
Background and aims Accumulating evidence suggests that the primary and acquired
resistance of hepatocellular carcinoma (HCC) to sorafenib is mediated by multiple …

The role of angiogenesis in hepatocellular carcinoma

MA Morse, W Sun, R Kim, AR He, PB Abada… - Clinical Cancer …, 2019 - AACR
Hepatocellular carcinoma (HCC) accounts for about 90% of all primary liver cancers and is
the second leading cause of cancer-related deaths worldwide. The hypervascular nature of …

The burden of primary liver cancer and underlying etiologies from 1990 to 2015 at the global, regional, and national level: results from the global burden of disease …

T Akinyemiju, S Abera, M Ahmed, N Alam… - JAMA …, 2017 - jamanetwork.com
Importance Liver cancer is among the leading causes of cancer deaths globally. The most
common causes for liver cancer include hepatitis B virus (HBV) and hepatitis C virus (HCV) …

[HTML][HTML] Sorafenib resistance in hepatocarcinoma: role of hypoxia-inducible factors

C Méndez-Blanco, F Fondevila… - … & molecular medicine, 2018 - nature.com
Sorafenib, a multikinase inhibitor with antiproliferative, antiangiogenic, and proapoptotic
properties, constitutes the only effective first-line drug approved for the treatment of …

Recent advances in hepatocellular carcinoma therapy

R Dutta, RI Mahato - Pharmacology & therapeutics, 2017 - Elsevier
Hepatocellular carcinoma (HCC), also called malignant hepatoma, is one of the deadliest
cancers due to its complexities, reoccurrence after surgical resection, metastasis and …

[HTML][HTML] Angiogenesis and immune checkpoint inhibitors as therapies for hepatocellular carcinoma: current knowledge and future research directions

M Hilmi, C Neuzillet, J Calderaro, F Lafdil… - … for immunotherapy of …, 2019 - Springer
Hepatocellular carcinoma (HCC) is the second deadliest cancer worldwide, due to its high
incidence and poor prognosis. Frequent initial presentation at advanced stages along with …

[HTML][HTML] Epidemiology of non-alcoholic fatty liver disease and hepatocellular carcinoma

ZM Younossi, L Henry - JHep Reports, 2021 - Elsevier
The prevalence of hepatocellular carcinoma (HCC) is increasing worldwide, whereas that of
most other cancers is decreasing. Non-alcoholic fatty liver disease (NAFLD), which has …

[HTML][HTML] Apigetrin promotes TNFα-induced apoptosis, necroptosis, G2/M phase cell cycle arrest, and ROS generation through inhibition of NF-κB pathway in Hep3B …

PB Bhosale, A Abusaliya, HH Kim, SE Ha, MY Park… - Cells, 2022 - mdpi.com
Apigetrin (7-(β-D-glucopyranosyloxy)-4′, 5-dihydroxyflavone), a glycoside bioactive dietary
flavonoid derived from Taraxacum officinale and Teucrium gnaphalodes, is known to …