Selective vulnerability of specific brain regions and cell populations is a hallmark of
neurodegenerative disorders. Mechanisms of selective vulnerability involve neuronal …

Friedreich ataxia (FA) is an inherited autosomal recessive neurodegenerative disease
(NDD) characterized primarily by progressive sensory and spinocerebellar ataxia …

Animals live in habitats fraught with a range of environmental challenges to their bodies and
brains. Accordingly, cells and organ systems have evolved stress-responsive signaling …

The immune system substantially influences age-related cognitive decline and Alzheimer's
disease (AD) progression, affected by genetic and environmental factors. In a Mayo Clinic …

Background Methamphetamine (METH) is a highly addictive stimulant that has become one
of the top five risk substances cause deaths from substance abuse. METH exposure …

Although apoptosis, pyroptosis, and ferroptosis have been implicated in AD, none fully
explains the extensive neuronal loss observed in AD brains. Recent evidence shows that …

Simple Summary Neurodegenerative diseases, such as Alzheimer's, Parkinson's, and
Huntington's diseases, cause immense suffering to patients and their families. Despite an …

Cognitive reserve is the ability to actively cope with brain deterioration and delay cognitive
decline in neurodegenerative diseases. It operates by optimizing performance through …

Interneuron loss is a prominent feature of temporal lobe epilepsy in both animals and
humans and is hypothesized to be critical for epileptogenesis. As loss occurs concurrently …

Abstract Background Patients with Alzheimer's Disease (AD) exhibit structural alterations of
the thalamus that correlate with clinical symptoms. However, given the anatomical …