Chronic kidney disease (CKD), characterized as renal dysfunction, is recognized as a major
public health problem with high morbidity and mortality worldwide. Unfortunately, there are …

The existence of salinity stress can be traced well before the domestication of crops, but the
documentation and mitigation of this menace started only 100 years ago. Due to the …

Mendelian randomisation (MR) analysis is an important tool to elucidate the causal
relevance of environmental and biological risk factors for disease. However, causal …

The kidneys operate at the interface of plasma and urine by clearing molecular waste
products while retaining valuable solutes. Genetic studies of paired plasma and urine …

Membranous Nephropathy (MN) is a rare autoimmune cause of kidney failure. Here we
report a genome-wide association study (GWAS) for primary MN in 3,782 cases and 9,038 …

Genetic studies of blood pressure (BP) to date have mainly analyzed common variants
(minor allele frequency> 0.05). In a meta-analysis of up to~ 1.3 million participants, we …

The kidney is an organ of key relevance to blood pressure (BP) regulation, hypertension and
antihypertensive treatment. However, genetically mediated renal mechanisms underlying …

Poor metabolic control and host genetic predisposition are critical for diabetic kidney
disease (DKD) development. The epigenome integrates information from sequence …

Aims Obesity and kidney diseases are common complex disorders with an increasing
clinical and economic impact on healthcare around the globe. Our objective was to examine …

Pediatric steroid-sensitive nephrotic syndrome (pSSNS) is the most common childhood
glomerular disease. Previous genome-wide association studies (GWAS) identified a risk …