Growth hormone in fertility and infertility: Mechanisms of action and clinical applications

CW Chang, YW Sung, YW Hsueh, YY Chen… - Frontiers in …, 2022 - frontiersin.org
Secreted by the anterior pituitary gland, growth hormone (GH) is a peptide that plays a
critical role in regulating cell growth, development, and metabolism in multiple targeted …

The clinical application of growth hormone and its biological and molecular mechanisms in assisted reproduction

P Pan, X Huang - International Journal of Molecular Sciences, 2022 - mdpi.com
Growth hormone (GH) has been used as a co-gonadotrophin in assisted reproduction,
particularly in poor ovarian responders. The application of GH has been alleged to activate …

Importance of IGF-I levels in IVF: potential relevance for growth hormone (GH) supplementation

N Gleicher, SK Darmon, E Molinari, P Patrizio… - Journal of assisted …, 2022 - Springer
Purpose Growth hormone (GH) supplementation in association with in vitro fertilization (IVF)
is worldwide again increasing, even though study outcomes have been discrepant. Since …

Preclinical evaluation of the ROCK1 inhibitor, GSK269962A, in acute myeloid leukemia

T Pan, S Wang, H Feng, J Xu, M Zhang… - Frontiers in …, 2022 - frontiersin.org
Acute myeloid leukemia (AML) is an aggressive hematologic malignancy with high mortality
that urgently requires new treatments. ROCK1 plays an essential role in regulating growth …

The effect of growth hormone adjuvant therapy on assisted reproductive technologies outcomes in patients with diminished ovarian reserve or poor ovarian response

S Dogan, OSY Cicek, M Demir, L Yalcinkaya… - Journal of gynecology …, 2021 - Elsevier
Low response of patients with diminished ovarian reserve to exogenous gonadotropins in
controlled ovarian stimulation (COS) protocols is one of the important problems of …

Comparative efficacy of different growth hormone supplementation protocols in improving clinical outcomes in women with poor ovarian response undergoing …

Z Xu, W Tong, Z Yang, H Zhang, X Chen - Scientific Reports, 2024 - nature.com
Growth hormone (GH) has a long-standing history of use as an adjunctive therapy in the
treatment of poor ovarian response (POR), but the optimal dosage and timing remains …

Effect of growth hormone cotreatment in sub-fertile women≥ 40 years: a meta-analysis

M Elkalyoubi, L Schindler… - Reproduction and Fertility, 2023 - raf.bioscientifica.com
Treatment of sub-fertile women aged≥ 40 years old (advanced maternal age (AMA)) is
challenging. Co-treatment with growth hormone (GH) is suggested to improve reproductive …

Human growth hormone use in poor ovarian response–caution and opportunities

RJ Norman, RJ Hart - Therapeutic advances in reproductive …, 2021 - journals.sagepub.com
Human growth hormone has found favour as a co-gonadotrophin in assisted reproduction
particularly in the circumstances of a poor response to stimulation. Its use has been based …

Supplementation of the in vitro maturation culture medium of mouse oocytes with growth hormone improves pregnancy outcomes

Y Lin, B Xie, X Li, R Li, C Ma, J Zhu, J Qiao - Reproductive Sciences, 2021 - Springer
This study aimed to examine the effects of adding growth hormone (GH) into the in vitro
maturation (IVM) culture medium of mouse oocytes on pregnancy outcomes. Cumulus …

The effect of human growth hormone on endometrial growth in controlled ovarian hyperstimulation cycles

B Bavan, RM Gardner, WY Zhang… - Journal of Personalized …, 2022 - mdpi.com
This study aims to compare endometrial growth before and after the addition of human
growth hormone (hGH) in controlled ovarian hyperstimulation (COH) cycles. A 5-year …