The present review aims to provide an update on health risks associated with the low-to-
moderate levels of environmental cadmium (Cd) and lead (Pb) to which most populations …

Acute kidney injury (AKI) is a common clinical state resulting from pathogenic conditions
such as ischemic and toxic insults. The pathophysiology of AKI shares common pathogenic …

The development of drugs with rapid distribution in the kidney and long-term retention in the
renal tubule is a breakthrough for enhanced treatment of acute kidney injury (AKI). Here, l …

Diabetic kidney disease (DKD) is the primary cause of chronic kidney disease around the
globe and is one of the main complications in patients with type 1 and 2 diabetes. The …

Acute kidney injury (AKI) and chronic kidney disease (CKD) are interconnected conditions,
and CKD is projected to become the fifth leading global cause of death by 2040. New …

Acute kidney injury (AKI), defined as a rapid decrease in glomerular filtration rate, is a
common and devastating pathologic condition. AKI is associated with significant morbidity …

Lipotoxicity is characterized by the ectopic accumulation of lipids in organs different from
adipose tissue. Lipotoxicity is mainly associated with dysfunctional signaling and insulin …

Tubulointerstitial fibrosis (TIF) is the hallmark of chronic kidney disease and best predictor of
renal survival. Many different cell types contribute to TIF progression including tubular …

An increasing number of studies suggest that the renal proximal tubule is a site of injury in
diabetic nephropathy (DN), and progressive renal tubulointerstitial fibrosis is an important …

A major obstacle in diabetes is the metabolic or hyperglycemic memory, which lacks specific
therapies. Here we show that glucose-mediated changes in gene expression largely persist …