Spinal cord injury: molecular mechanisms and therapeutic interventions

X Hu, W Xu, Y Ren, Z Wang, X He, R Huang… - Signal transduction and …, 2023 - nature.com
Spinal cord injury (SCI) remains a severe condition with an extremely high disability rate.
The challenges of SCI repair include its complex pathological mechanisms and the …

Epidemiology of traumatic spinal cord injury in developing countries from 2009 to 2020: a systematic review and meta-analysis

A Golestani, P Shobeiri, M Sadeghi-Naini… - …, 2022 - karger.com
Introduction: Traumatic spinal cord injury (TSCI) is a catastrophic event with a considerable
health and economic burden on individuals and countries. This study was performed to …

Global neurosurgery: the current capacity and deficit in the provision of essential neurosurgical care. Executive Summary of the Global Neurosurgery Initiative at the …

MC Dewan, A Rattani, G Fieggen, MA Arraez… - Journal of …, 2018 - thejns.org
OBJECTIVE Worldwide disparities in the provision of surgical care result in otherwise
preventable disability and death. There is a growing need to quantify the global burden of …

A DAMP-scavenging, IL-10-releasing hydrogel promotes neural regeneration and motor function recovery after spinal cord injury

H Shen, B Xu, C Yang, W Xue, Z You, X Wu, D Ma… - Biomaterials, 2022 - Elsevier
Spinal cord injury (SCI) creates an inflammatory microenvironment characterized by
damage-associated molecular patterns (DAMPs) and immune cell activation that exacerbate …

Global, regional, and national burden of spinal cord injury, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

M Safdarian, E Trinka, V Rahimi-Movaghar… - The Lancet …, 2023 - thelancet.com
Background Spinal cord injury (SCI) is a major cause of health loss due to premature
mortality and long-term disability. We aimed to report on the global, regional, and national …

High-dose methylprednisolone for acute traumatic spinal cord injury: a meta-analysis

Z Liu, Y Yang, L He, M Pang, C Luo, B Liu, L Rong - Neurology, 2019 - AAN Enterprises
Objective Due to the continuing debates on the utility of high-dose methylprednisolone (MP)
early after acute spinal cord injury (ASCI), we aimed to evaluate the therapeutic and adverse …

Oxidative stress following spinal cord injury: From molecular mechanisms to therapeutic targets

M Yu, Z Wang, D Wang, M Aierxi, Z Ma… - Journal of …, 2023 - Wiley Online Library
Spinal cord injury (SCI) is a medical condition that results from severe trauma to the central
nervous system; it imposes great psychological and economic burdens on affected patients …

Stem cell therapies for acute spinal cord injury in humans: a review

MC Jin, ZA Medress, TD Azad, VM Doulames… - Neurosurgical …, 2019 - thejns.org
Recent advances in stem cell biology present significant opportunities to advance clinical
applications of stem cell–based therapies for spinal cord injury (SCI). In this review, the …

Systemic inflammation in traumatic spinal cord injury

O Bloom, PE Herman, AM Spungen - Experimental neurology, 2020 - Elsevier
There are 17,730 new cases of spinal cord injury annually in the United States and up to 2.5
million individuals estimated to be living with chronic spinal cord injury (SCI)(Herman and …

Transplantation of A2 type astrocytes promotes neural repair and remyelination after spinal cord injury

J Chang, Z Qian, B Wang, J Cao, S Zhang… - Cell Communication and …, 2023 - Springer
Background Limited progress in terms of an effective treatment for spinal cord injury (SCI)
emphasizes the urgent need for novel therapies. As a vital central nervous system …