Immunological memory is the residuum of a successful immune response that in the B cell
lineage comprises long-lived plasma cells and long-lived memory B cells. It is apparent that …

Highlights•Competition for Tfh drives GC B cell proliferation, mutation and affinity
maturation.•Relationship between IgA memory, the microbiota and maternally transmitted …

Psoriatic arthritis (PsA) is a chronic inflammatory arthritis associated with psoriasis. A third of
psoriatic patients develop PsA via unknown mechanisms. No reliable diagnostic markers …

The development of B and T cells from hematopoietic precursors and the regulation of the
functions of these immune cells are complex processes that involve highly regulated …

Hematopoietic development is governed by the coordinated expression of lineage-and
differentiation stage-specific genes. Transcription factors play major roles in this process and …

Lifelong antibody responses to vaccination require reorganization of lymphoid tissue and
dynamic intercellular communication called the germinal center reaction. B lymphocytes …

Over the last decade, the known spectrum of CD 4+ T‐cell effector subsets has become
much broader, and it has become clear that there are multiple dimensions by which subsets …

Objectives Follicular helper T (Tfh) cells exert an important role in autoimmune diseases.
Whether it might be involved in type 1 diabetes (T1D) is unknown. Our aim was to …

The BCL6 oncogenic repressor is a master regulator of humoral immunity and B-cell
lymphoma survival. Whereas much research has focused on its regulation and function in …

Background Despite reducing pneumonia and other infections, antibody replacement does
not appear to treat pulmonary lymphoid hyperplasia (PLH) in patients with common variable …