Impact of Genetic Polymorphisms of ABCB1 (MDR1, P-Glycoprotein) on Drug Disposition and Potential Clinical Implications: Update of the Literature
ATP-binding cassette transporter B1 (ABCB1; P-glycoprotein; multidrug resistance protein 1)
is an adenosine triphosphate (ATP)-dependent efflux transporter located in the plasma …
is an adenosine triphosphate (ATP)-dependent efflux transporter located in the plasma …
Effect of CYP3A and ABCB1 Single Nucleotide Polymorphisms on the Pharmacokinetics and Pharmacodynamics of Calcineurin Inhibitors: Part I
The calcineurin inhibitors ciclosporin (cyclosporine) and tacrolimus are immunosuppressant
drugs used for the prevention of organ rejection following transplantation. Both agents are …
drugs used for the prevention of organ rejection following transplantation. Both agents are …
A synonymous polymorphism in a common MDR1 (ABCB1) haplotype shapes protein function
KL Fung, MM Gottesman - Biochimica et Biophysica Acta (BBA)-Proteins …, 2009 - Elsevier
The MDR1 (ABCB1) gene encodes a membrane-bound transporter that actively effluxes a
wide range of compounds from cells. The overexpression of MDR1 by multidrug-resistant …
wide range of compounds from cells. The overexpression of MDR1 by multidrug-resistant …
ABCB1 Pharmacogenetics: Progress, Pitfalls, and Promise
LW Chinn, DL Kroetz - Clinical Pharmacology & Therapeutics, 2007 - Wiley Online Library
In 1976, Juliano and Ling 1 reported expression of a 170 kDa protein in colchicine‐resistant
Chinese hamster ovary (CHO) cells that was absent in drug‐sensitive cells. Because this …
Chinese hamster ovary (CHO) cells that was absent in drug‐sensitive cells. Because this …
Genetic and clinical determinants of early, acute calcineurin inhibitor-related nephrotoxicity: results from a kidney transplant consortium
PA Jacobson, D Schladt, A Israni, WS Oetting… - …, 2012 - journals.lww.com
Background. Calcineurin inhibitor (CNI)-related acute nephrotoxicity is a common
complication of transplantation. Clinical factors and elevated CNI levels are associated with …
complication of transplantation. Clinical factors and elevated CNI levels are associated with …
Pharmacogenetics of cyclosporine in children suggests an age-dependent influence of ABCB1 polymorphisms
Objective To evaluate whether variations in the ABCB1, ABCC2, SLCO1B1, CYP3A4,
CYP3A5, or NR1I2 genes are associated with the pharmacokinetics of cyclosporine in …
CYP3A5, or NR1I2 genes are associated with the pharmacokinetics of cyclosporine in …
Significant impact of gene polymorphisms on tacrolimus but not cyclosporine dosing in Asian renal transplant recipients
PT Loh, HX Lou, Y Zhao, YM Chin… - Transplantation …, 2008 - Elsevier
Calcineurin inhibitors (CNI) are metabolized by cytochrome-P4503A (CYP3A) enzymes and
extruded into the intestinal lumen by the drug efflux pump, P-glycoprotein (P-gp). The impact …
extruded into the intestinal lumen by the drug efflux pump, P-glycoprotein (P-gp). The impact …
Association between ABCB1 C3435T polymorphism and increased risk of cannabis dependence
A Benyamina, L Bonhomme-Faivre, V Picard… - Progress in Neuro …, 2009 - Elsevier
Prolonged cannabis use has a significant impact on health and well-being. Genetic factors
are known to influence cannabis dependence, but few specific genetic markers have been …
are known to influence cannabis dependence, but few specific genetic markers have been …
Colchicine-induced toxicity in a heart transplant patient with chronic renal failure
G Eleftheriou, G Bacis, R Fiocchi… - Clinical Toxicology, 2008 - Taylor & Francis
Introduction. Therapeutic doses of colchicine in patients with renal compromise and
cyclosporine therapy may result in increased plasma concentrations of colchicine and …
cyclosporine therapy may result in increased plasma concentrations of colchicine and …
Effect of genetic polymorphisms of CYP3A5 and MDR1 on cyclosporine concentration during the early stage after renal transplantation in Chinese patients co-treated …
Y Wang, C Wang, J Li, X Wang, G Zhu, X Chen… - European journal of …, 2009 - Springer
Objective The aim of this study was to assess the influence of the cytochrome (CYP450) 3A5
and multidrug resistance (MDR1) gene polymorphisms on cyclosporine A (CsA) trough …
and multidrug resistance (MDR1) gene polymorphisms on cyclosporine A (CsA) trough …