Animal cell-based expression platforms enable the production of complex biomolecules
such as recombinant proteins and viral vectors. Although most biotherapeutics are produced …

Lentiviruses are becoming an increasingly popular choice of gene transfer vehicle for use in
the treatment of a variety of genetic and acquired human diseases. As research progresses …

Adoptive transfer of tumor-infiltrating lymphocytes (TILs) and genetically engineered T
lymphocytes expressing chimeric antigen receptors (CARs) or conventional alpha/beta T …

γ9δ2T cells play a critical role in daily cancer immune surveillance by sensing cancer-
mediated metabolic changes. However, a major limitation of the therapeutic application of …

EPH receptors (EPHRs) constitute the largest family among receptor tyrosine kinases in
humans. They are mainly involved in short-range cell-cell communication events that …

Retroviral vectors derived from the Moloney murine leukemia virus have been used in
successful and promising gene therapy clinical trials. However, platforms for their large …

Mammalian cell cultures are increasingly used for the production of complex
biopharmaceuticals including viral vectors and vaccines. HEK293 is the predominant cell …

Recombinant adeno-associated virus (rAAV) is the most effective viral vector technology for
directly translating the genomic revolution into medicinal therapies. However, the …

Cell and gene therapies are finally becoming viable patient treatment options, with both T
cell-and hematopoietic stem cell (HSC)-based therapies being approved to market in …

In this study, we showed that a codon optimized version of the spike (S) protein of SARS-
CoV-2 can migrate to the cell membrane. However, efficient production of Moloney murine …