Challenges and opportunities in cancer drug resistance

RA Ward, S Fawell, N Floc'h, V Flemington… - Chemical …, 2020 - ACS Publications
There has been huge progress in the discovery of targeted cancer therapies in recent years.
However, even for the most successful and impactful cancer drugs which have been …

Nanotechnological approaches in prostate cancer therapy: integration of engineering and biology

M Ashrafizadeh, S Aghamiri, SC Tan, A Zarrabi… - Nano Today, 2022 - Elsevier
Nanocarriers have received special attention in biomedicine for the treatment of various
diseases, especially cancer, as one of the leading causes of death worldwide. Nanocarriers …

Tumor cell plasticity in targeted therapy-induced resistance: mechanisms and new strategies

ZD Shi, K Pang, ZX Wu, Y Dong, L Hao… - … and Targeted Therapy, 2023 - nature.com
Despite the success of targeted therapies in cancer treatment, therapy-induced resistance
remains a major obstacle to a complete cure. Tumor cells evade treatments and relapse via …

Targeting signaling pathways in prostate cancer: mechanisms and clinical trials

Y He, W Xu, YT Xiao, H Huang, D Gu… - Signal transduction and …, 2022 - nature.com
Prostate cancer (PCa) affects millions of men globally. Due to advances in understanding
genomic landscapes and biological functions, the treatment of PCa continues to improve …

Single-cell analysis of human primary prostate cancer reveals the heterogeneity of tumor-associated epithelial cell states

H Song, HNW Weinstein, P Allegakoen… - Nature …, 2022 - nature.com
Prostate cancer is the second most common malignancy in men worldwide and consists of a
mixture of tumor and non-tumor cell types. To characterize the prostate cancer tumor …

Extracellular vesicles as a source of prostate cancer biomarkers in liquid biopsies: a decade of research

M Ramirez-Garrastacho, C Bajo-Santos, A Line… - British journal of …, 2022 - nature.com
Prostate cancer is a global cancer burden and considerable effort has been made through
the years to identify biomarkers for the disease. Approximately a decade ago, the potential of …

Emerging role of exosomes as biomarkers in cancer treatment and diagnosis

NA Hanjani, N Esmaelizad, S Zanganeh… - Critical reviews in …, 2022 - Elsevier
Cancer is a leading cause of death worldwide and cancer incidence and mortality are
rapidly growing. These massive amounts of cancer patients require rapid diagnosis and …

[HTML][HTML] Targeting SREBP-2-regulated mevalonate metabolism for cancer therapy

L Xue, H Qi, H Zhang, L Ding, Q Huang, D Zhao… - Frontiers in …, 2020 - frontiersin.org
Recently, targeting metabolic reprogramming has emerged as a potential therapeutic
approach for fighting cancer. Sterol regulatory element binding protein-2 (SREBP-2), a basic …

Protein palmitoylation in cancer: molecular functions and therapeutic potential

B Zhou, Q Hao, Y Liang, E Kong - Molecular oncology, 2023 - Wiley Online Library
Protein S‐palmitoylation (hereinafter referred to as protein palmitoylation) is a reversible
lipid posttranslational modification catalyzed by the zinc finger DHHC‐type containing …

Targeting CDK9 for anti-cancer therapeutics

R Mandal, S Becker, K Strebhardt - Cancers, 2021 - mdpi.com
Simple Summary CDK9, in combination with Cyclin T1, is one of the major regulators of RNA
Polymerase II mediated productive transcription of critical genes in any cell. The activity of …