Network pharmacology, a promising approach to reveal the pharmacology mechanism of Chinese medicine formula
L Zhao, H Zhang, N Li, J Chen, H Xu, Y Wang… - Journal of …, 2023 - Elsevier
Ethnopharmacological relevance Network pharmacology is a new discipline based on
systems biology theory, biological system network analysis, and multi-target drug molecule …
systems biology theory, biological system network analysis, and multi-target drug molecule …
Research progress on the pathogenesis of knee osteoarthritis
X Du, Z Liu, X Tao, Y Mei, D Zhou, K Cheng… - Orthopaedic …, 2023 - Wiley Online Library
Knee osteoarthritis (KOA) is a chronic joint bone disease characterized by inflammatory
destruction and hyperplasia of bone. Its main clinical symptoms are joint mobility difficulties …
destruction and hyperplasia of bone. Its main clinical symptoms are joint mobility difficulties …
The gut microbiota metabolite capsiate regulate SLC2A1 expression by targeting HIF‐1α to inhibit knee osteoarthritis‐induced ferroptosis
Z Guan, X Jin, Z Guan, S Liu, K Tao, L Luo - Aging Cell, 2023 - Wiley Online Library
Ferroptosis is an iron‐dependent cell death that has been found to aggravate the
progression of osteoarthritis (OA) and gut microbiota‐OA axis refers to the bidirectional …
progression of osteoarthritis (OA) and gut microbiota‐OA axis refers to the bidirectional …
[HTML][HTML] Nav1.7 as a chondrocyte regulator and therapeutic target for osteoarthritis
W Fu, D Vasylyev, Y Bi, M Zhang, G Sun… - Nature, 2024 - nature.com
Osteoarthritis (OA) is the most common joint disease. Currently there are no effective
methods that simultaneously prevent joint degeneration and reduce pain. Although limited …
methods that simultaneously prevent joint degeneration and reduce pain. Although limited …
[HTML][HTML] Mesenchymal stem cell mechanisms of action and clinical effects in osteoarthritis: a narrative review
With the insufficient satisfaction rates and high cost of operative treatment for osteoarthritis
(OA), alternatives have been sought. Furthermore, the inability of current medications to …
(OA), alternatives have been sought. Furthermore, the inability of current medications to …
[HTML][HTML] The involvement of neutrophils in the pathophysiology and treatment of osteoarthritis
S Chaney, R Vergara, Z Qiryaqoz, K Suggs, A Akkouch - Biomedicines, 2022 - mdpi.com
Osteoarthritis (OA) is a chronic disability that significantly impairs quality of life. OA is one of
the most prevalent joint pathologies in the world, characterized by joint pain and stiffness …
the most prevalent joint pathologies in the world, characterized by joint pain and stiffness …
[HTML][HTML] Osteoarthritis animal models for biomaterial-assisted osteochondral regeneration
Y Wang, Y Chen, Y Wei - Biomaterials translational, 2022 - ncbi.nlm.nih.gov
Clinical therapeutics for the regeneration of osteochondral defects (OCD) in the early stages
of osteoarthritis remain an enormous challenge in orthopaedics. For in-depth studies of …
of osteoarthritis remain an enormous challenge in orthopaedics. For in-depth studies of …
[HTML][HTML] A new strategy for osteoarthritis therapy: Inhibition of glycolysis
C Tan, L Li, J Han, K Xu, X Liu - Frontiers in Pharmacology, 2022 - frontiersin.org
Osteoarthritis (OA) is a common degenerative disease of the joints. It is primarily caused by
age, obesity, mechanical damage, genetics, and other factors, leading to cartilage …
age, obesity, mechanical damage, genetics, and other factors, leading to cartilage …
Associations between markers of inflammation and altered pain perception mechanisms in people with knee osteoarthritis: a systematic review
P Dainese, H Mahieu, S De Mits, R Wittoek… - RMD open, 2023 - rmdopen.bmj.com
To provide an extensive review on the associations between knee inflammation and altered
pain perception mechanisms in people with knee osteoarthritis (OA). MEDLINE, Web of …
pain perception mechanisms in people with knee osteoarthritis (OA). MEDLINE, Web of …
[HTML][HTML] Inflammatory and metabolic signaling interfaces of the hypertrophic and senescent chondrocyte phenotypes associated with osteoarthritis
Osteoarthritis (OA) is a complex disease of whole joints with progressive cartilage matrix
degradation and chondrocyte transformation. The inflammatory features of OA are reflected …
degradation and chondrocyte transformation. The inflammatory features of OA are reflected …