Simple Summary Among all types of cancer, Pancreatic Ductal Adenocarcinoma (PDAC)
has one of the lowest survival rates, partly due to the failure of current chemotherapeutics …

Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest cancers worldwide,
primarily due to its robust desmoplastic stroma and immunosuppressive tumor …

Pyruvate dehydrogenase kinases (PDKs) are serine/threonine kinases, that are directly
involved in altered cancer cell metabolism, resulting in cancer aggressiveness and …

Background Tumor-initiating cells (TIC), also known as cancer stem cells, are considered a
specific subpopulation of cells necessary for cancer initiation and metastasis; however, the …

Pancreatic ductal adenocarcinoma (PDAC) mainly develops in the head of the pancreas,
within the acino-ductal unit composed of acinar and ductal cells surrounded by pancreatic …

The design of powerful in vitro cell culture platforms to support precision medicine can
contribute to predict therapeutic success of cancer patients. Electrospun nanofibers applied …

Aims This study aims to evaluate ECM-coated micropattern arrays derived from
decellularization of native porcine lungs as a novel three-dimensional cell culture platform …

Abstract 3D cell cultures are becoming the new standard for cell-based in vitro research, due
to their higher transferrability toward in vivo biology. The lack of established techniques for …

The detection of extracellular pH at single cell resolution is challenging and requires
advanced sensibility. Sensing pH at a high spatial and temporal resolution might provide …

The constant increase in cancer incidence and mortality pushes biomedical research
towards the development of in vitro 3D systems able to faithfully reproduce and effectively …