Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …

Despite recent advances in the development of anti-asthmatic medication, asthma continues
to be a major health problem worldwide. The symptoms of asthmatic patients include …

Tachykinins (TKs) are small peptides widely distributed in the central and peripheral
nervous systems where they act as neurotransmitters. Potent and selective TKs antagonists …

Background Tachykinins have been implicated in the pathophysiology of IBS with diarrhoea
(IBS-D). Our aim was to study the efficacy and safety of ibodutant, a selective neurokinin-2 …

Background Tachykinins (TK s) are a family of endogenous peptides widely expressed in
the central and in the peripheral nervous systems as well as in the gastrointestinal (GI) tract …

HT receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on 5-HT receptors
[194] and subsequently revised [176]) are, with the exception of the ionotropic 5-HT 3 class …

Tachykinins act as neurotransmitters and neuromodulators in the central and peripheral
nervous system. Preclinical studies and clinical trials showed that inhibition of the tachykinin …

Tachykinin NK receptors (NKRs) differ to a large degree among species with respect to their
affinities for small molecule antagonists. The aims of the present study were to clone NKRs …

Introduction The development of novel analgesics to treat acute or chronic pain has been a
challenge due to a lack of translatable measurements. Preclinical end points with improved …

The sensory neuropeptides secretoneurin (SN) and substance P (SP) are involved in
“neurogenic” inflammatory processes as they occur in bronchial asthma or allergic rhinitis. A …