Interleukin 6 in diabetes, chronic kidney disease, and cardiovascular disease: mechanisms and therapeutic perspectives
FF Kreiner, JM Kraaijenhof, M von Herrath… - Expert Review of …, 2022 - Taylor & Francis
Introduction Diabetes, chronic kidney disease (CKD) and cardiovascular disease (CVD) are
cardiometabolic diseases that remain amongst the leading causes of morbidity and …
cardiometabolic diseases that remain amongst the leading causes of morbidity and …
[HTML][HTML] MicroRNA-34a: the bad guy in age-related vascular diseases
A Raucci, F Macrì, S Castiglione, I Badi… - Cellular and Molecular …, 2021 - Springer
The age-related vasculature alteration is the prominent risk factor for vascular diseases
(VD), namely, atherosclerosis, abdominal aortic aneurysm, vascular calcification (VC) and …
(VD), namely, atherosclerosis, abdominal aortic aneurysm, vascular calcification (VC) and …
[HTML][HTML] Genetic insights into therapeutic targets for aortic aneurysms: A Mendelian randomization study
Y Chen, X Xu, L Wang, K Li, Y Sun, L Xiao, J Dai… - …, 2022 - thelancet.com
Summary Background As aortic aneurysms (AAs) enlarge, they can become life-threatening
if left undiagnosed or neglected. At present, there is a lack of radical treatments for …
if left undiagnosed or neglected. At present, there is a lack of radical treatments for …
Multifunctional role of nanoparticles for the diagnosis and therapeutics of cardiovascular diseases
I Arshad, A Kanwal, I Zafar, A Unar, M Hanane… - Environmental …, 2023 - Elsevier
The increasing burden of cardiovascular disease (CVD) remains responsible for morbidity
and mortality worldwide; their effective diagnostic or treatment methods are of great interest …
and mortality worldwide; their effective diagnostic or treatment methods are of great interest …
[HTML][HTML] Inflammasomes in the pathophysiology of aortic disease
M Wortmann, AS Peters, P Erhart, D Körfer, D Böckler… - Cells, 2021 - mdpi.com
Aortic diseases comprise aneurysms, dissections, and several other pathologies. In general,
aging is associated with a slow but progressive dilation of the aorta, along with increased …
aging is associated with a slow but progressive dilation of the aorta, along with increased …
Early Progression of Abdominal Aortic Aneurysm is Decelerated by Improved Endothelial Barrier Function via ALDH2‐LIN28B‐ELK3 Signaling
K Yang, S Cui, J Wang, T Xu, H Du, H Yue… - Advanced …, 2023 - Wiley Online Library
The involvement of endothelial barrier function in abdominal aortic aneurysm (AAA) and its
upstream regulators remains unknown. Single‐cell RNA sequencing shows that disrupted …
upstream regulators remains unknown. Single‐cell RNA sequencing shows that disrupted …
[HTML][HTML] Association between the non-HDL-cholesterol to HDL-cholesterol ratio and abdominal aortic aneurysm from a Chinese screening program
W Lin, S Luo, W Li, J Liu, T Zhou, F Yang… - Lipids in Health and …, 2023 - Springer
Abstract Background Abdominal aortic aneurysms (AAAs) can result in high mortality upon
rupture but are usually undiagnosed because of the absence of symptoms in the early stage …
rupture but are usually undiagnosed because of the absence of symptoms in the early stage …
[HTML][HTML] The future for the therapeutics of abdominal aortic aneurysm: engineered nanoparticles drug delivery for abdominal aortic aneurysm
P Du, Y Hou, C Su, J Gao, Y Yang, J Zhang… - … in Bioengineering and …, 2024 - frontiersin.org
Abdominal aortic aneurysm (AAA) is a severe cardiovascular disease with a high mortality
rate. Several screening and diagnostic methods have been developed for AAA early …
rate. Several screening and diagnostic methods have been developed for AAA early …
[HTML][HTML] Platelet protects angiotensin II-driven abdominal aortic aneurysm formation through inhibition of inflammation
X Liu, X Chen, C Xu, J Lou, Y Weng, L Tang - Experimental gerontology, 2022 - Elsevier
Background Inflammation is the primary cause of abdominal aortic aneurysm (AAA)
formation and development. It has been reported that platelets protect against septic shock …
formation and development. It has been reported that platelets protect against septic shock …
[HTML][HTML] Doxycycline induces mitochondrial dysfunction in aortic smooth muscle cells
The antibiotic doxycycline is known to inhibit inflammation and was therefore considered as
a therapeutic to prevent abdominal aortic aneurysm (AAA) growth. Yet mitochondrial …
a therapeutic to prevent abdominal aortic aneurysm (AAA) growth. Yet mitochondrial …