Extensive studies on HIV-1 have led to the discovery of a variety of structurally and
functionally diverse innate defense factors that target various steps of the retroviral …

Zika virus (ZIKV) poses a serious threat to the entire world. The rapid spread of ZIKV and
recent outbreaks since 2007 have caused worldwide concern about the virus. Diagnosis is …

The innate immune system features a web of interacting pathways that require exquisite
regulation. To identify novel nodes in this immune landscape, we conducted a gain-of …

Innate antiviral factors are essential for effective defense against viral pathogens. However,
the identity of major restriction mechanisms remains elusive. Current approaches to discover …

Genetic screens have transformed our ability to interrogate cellular factor requirements for
viral infections,, but most current approaches are limited in their sensitivity, biased towards …

The RNA cap methyltransferase CMTR1 methylates the first transcribed nucleotide of RNA
polymerase II transcripts, impacting gene expression mechanisms, including during innate …

The host-virus interactome is increasingly recognized as an important research field to
discover new therapeutic targets to treat influenza. Multiple pooled genome-wide CRISPR …

The innate immune system features a web of interacting pathways that require exquisite
regulation. To identify novel nodes in this immune landscape we conducted a gain of …

The time interval between HIV-1 infection and AIDS development is not the same in all
patients and depends largely on the genetic background of the individual. Polymorphisms in …

The stimulator of interferon genes (STING), an integral adaptor protein in the DNA-sensing
pathway, plays a pivotal role in the innate immune response against infections. Additionally …