Induced pluripotent stem cells in disease modelling and drug discovery
The derivation of induced pluripotent stem cells (iPSCs) over a decade ago sparked
widespread enthusiasm for the development of new models of human disease, enhanced …
widespread enthusiasm for the development of new models of human disease, enhanced …
[HTML][HTML] Human-specific genetics: new tools to explore the molecular and cellular basis of human evolution
Our ancestors acquired morphological, cognitive and metabolic modifications that enabled
humans to colonize diverse habitats, develop extraordinary technologies and reshape the …
humans to colonize diverse habitats, develop extraordinary technologies and reshape the …
Determinants of telomere length across human tissues
K Demanelis, F Jasmine, LS Chen, M Chernoff, L Tong… - Science, 2020 - science.org
INTRODUCTION Telomeres are DNA-protein complexes located at the end of chromosomes
that protect chromosome ends from degradation and fusion. The DNA component of …
that protect chromosome ends from degradation and fusion. The DNA component of …
Addressing variability in iPSC-derived models of human disease: guidelines to promote reproducibility
Induced pluripotent stem cell (iPSC) technologies have provided in vitro models of
inaccessible human cell types, yielding new insights into disease mechanisms especially for …
inaccessible human cell types, yielding new insights into disease mechanisms especially for …
Enhancer release and retargeting activates disease-susceptibility genes
The functional engagement between an enhancer and its target promoter ensures precise
gene transcription. Understanding the basis of promoter choice by enhancers has important …
gene transcription. Understanding the basis of promoter choice by enhancers has important …
The consequences of recurrent genetic and epigenetic variants in human pluripotent stem cells
It is well established that human pluripotent stem cells (hPSCs) can acquire genetic and
epigenetic changes during culture in vitro. Given the increasing use of hPSCs in research …
epigenetic changes during culture in vitro. Given the increasing use of hPSCs in research …
Common genetic variation drives molecular heterogeneity in human iPSCs
Technology utilizing human induced pluripotent stem cells (iPS cells) has enormous
potential to provide improved cellular models of human disease. However, variable genetic …
potential to provide improved cellular models of human disease. However, variable genetic …
[HTML][HTML] Cardiovascular disease models: a game changing paradigm in drug discovery and screening
H Savoji, MH Mohammadi, N Rafatian, MK Toroghi… - Biomaterials, 2019 - Elsevier
Cardiovascular disease is the leading cause of death worldwide. Although investment in
drug discovery and development has been sky-rocketing, the number of approved drugs has …
drug discovery and development has been sky-rocketing, the number of approved drugs has …
[HTML][HTML] Human neuronal networks on micro-electrode arrays are a highly robust tool to study disease-specific genotype-phenotype correlations in vitro
B Mossink, AHA Verboven, EJH van Hugte… - Stem cell reports, 2021 - cell.com
Micro-electrode arrays (MEAs) are increasingly used to characterize neuronal network
activity of human induced pluripotent stem cell (hiPSC)-derived neurons. Despite their gain …
activity of human induced pluripotent stem cell (hiPSC)-derived neurons. Despite their gain …
A computational model of induced pluripotent stem‐cell derived cardiomyocytes incorporating experimental variability from multiple data sources
Key points Induced pluripotent stem cell‐derived cardiomyocytes (iPSC‐CMs) capture
patient‐specific genotype–phenotype relationships, as well as cell‐to‐cell variability of …
patient‐specific genotype–phenotype relationships, as well as cell‐to‐cell variability of …