Obesity and its complications have become a prominent global public health problem that
severely threatens human health. Melatonin, originally known as an effective antioxidant, is …

Cancer is a large group of diseases and the second leading cause of death worldwide.
Lung, prostate, colorectal, stomach, and liver cancers are the most common types of cancer …

Circadian clock disorder during tissue degeneration has been considered the potential
pathogenesis for various chronic diseases, such as intervertebral disc degeneration (IVDD) …

The evolutionarily ancient methoxyindoleamine, melatonin, has long perplexed investigators
by its versatility of functions and mechanisms of action, which include the regulation of …

Circadian rhythms are biological systems that synchronize cellular circadian oscillators with
the organism's daily feeding-fasting or rest-activity cycles in mammals. Circadian rhythms …

The circadian clock acts a pivotal part in human daily physiology and metabolism. Excess
alcohol consumption disturbs the circadian rhythm of several metabolism-related genes of …

Background: Melatonin is an indolic compound mainly secreted by the pineal gland and
plays a vital role in the regulation of circadian rhythms and cancer therapy. However, the …

Our daily rhythmicity is controlled by a circadian clock with a specific set of genes located in
the suprachiasmatic nucleus in the hypothalamus. Mast cells (MCs) are major effector cells …

Despite the evolving advances in clinical approaches to obesity and its inherent
comorbidities, the therapeutic challenge persists. Among several pharmacological tools …

Influenza A virus (IAV) H1N1 infection is a constant threat to human health and it remains so
due to the lack of an effective treatment. Since melatonin is a potent antioxidant and anti …