Competitive mirror image phage display derived peptide modulates amyloid beta aggregation and toxicity
S Rudolph, AN Klein, M Tusche, C Schlosser, A Elfgen… - PloS one, 2016 - journals.plos.org
Alzheimer´ s disease is the most prominent type of dementia and currently no causative
treatment is available. According to recent studies, oligomeric species of the amyloid beta …
treatment is available. According to recent studies, oligomeric species of the amyloid beta …
Nanoscale interplay of membrane composition and amyloid self-assembly
Cell membranes are complex assemblies of lipids and proteins exhibiting lipid
compositional heterogeneity between the inner and outer leaflets of the bilayer. Aberrant …
compositional heterogeneity between the inner and outer leaflets of the bilayer. Aberrant …
Highlighting the effect of amyloid beta assemblies on the mechanical properties and conformational stability of cell membrane
Alzheimer disease (AD) is the most common cause of dementia, characterized by a
progressive decline in cognitive function due to the abnormal aggregation and deposition of …
progressive decline in cognitive function due to the abnormal aggregation and deposition of …
A Linear Fit for Atomic Force Microscopy Nanoindentation Experiments on Soft Samples
SV Kontomaris, A Malamou, A Zachariades… - Processes, 2024 - mdpi.com
Atomic Force Microscopy (AFM) nanoindentation is a powerful technique for determining the
mechanical properties of soft samples at the nanoscale. The Hertz model is typically used for …
mechanical properties of soft samples at the nanoscale. The Hertz model is typically used for …
Structural model for self-limiting β-strand arrangement within an Alzheimer's amyloid-β oligomer
Previous reports revealed that sodium dodecyl sulfate near its critical micelle concentration
can drive the assembly of Aβ42 along an oligomeric pathway. This pathway produces a 150 …
can drive the assembly of Aβ42 along an oligomeric pathway. This pathway produces a 150 …
[HTML][HTML] Amyloid pore-channel hypothesis: effect of ethanol on aggregation state using frog oocytes for an Alzheimer's disease study
J Parodi, D Ormeño, LD Ochoa-de la Paz - BMB reports, 2015 - ncbi.nlm.nih.gov
Alzheimer's disease severely compromises cognitive function. One of the mechanisms to
explain the pathology of Alzheimer's disease has been the hypotheses of amyloid …
explain the pathology of Alzheimer's disease has been the hypotheses of amyloid …
Graphene nanopore support system for simultaneous high-resolution AFM imaging and conductance measurements
Accurately defining the nanoporous structure and sensing the ionic flow across nanoscale
pores in thin films and membranes has a wide range of applications, including …
pores in thin films and membranes has a wide range of applications, including …
Fluorescence quenching by lipid encased nanoparticles shows that amyloid-β has a preferred orientation in the membrane
Short range plasmonic fields around a nanoparticle can modulate fluorescence or Raman
processes. In lipid encased nanoparticles, this can potentially measure the relative depths of …
processes. In lipid encased nanoparticles, this can potentially measure the relative depths of …
The role of alpha-helix on the structure-targeting drug design of amyloidogenic proteins
The most accredited hypothesis links the toxicity of amyloid proteins to their harmful effects
on membrane integrity through the formation of prefibrillar-transient oligomers able to disrupt …
on membrane integrity through the formation of prefibrillar-transient oligomers able to disrupt …
Single-molecule studies of amyloid proteins: from biophysical properties to diagnostic perspectives
In neurodegenerative diseases, a wide range of amyloid proteins or peptides such as
amyloid-beta and α-synuclein fail to keep native functional conformations, followed by …
amyloid-beta and α-synuclein fail to keep native functional conformations, followed by …