Enhancer of zeste homolog 2 (EZH2) is enzymatic catalytic subunit of polycomb repressive
complex 2 (PRC2) that can alter downstream target genes expression by trimethylation of …

EZH2, the catalytic subunit of PRC2, catalyzes histone H3 lysine 27 (H3K27) trimethylation
to induce the agglutination of chromosomes and in turn represses the transcription of the …

Epigenetic changes associated with histone modifications play an important role in the
emergence and maintenance of the phenotype of various cancer types. In contrast to direct …

Enhancer of zeste homolog 2 (EZH2), a catalytic subunit of polycomb repressive complex 2
(PRC2), is overexpressed in triple-negative breast cancer (TNBC), correlating with poor …

Chromatin modifications–including DNA methylation, modification of histones and
recruitment of noncoding RNAs–are essential epigenetic events. Multiple sequential …

Gastric cancer (GC) is one of the most common and deadly cancers in the world. It is a
multifactorial disease highly influenced by environmental factors, which include radiation …

We aimed to investigate the bio‐functions of METTL3 in promoting breast cancer (BCa)
progression via regulating N6‐methyladenosine (m6A) modification of EZH2 mRNA …

Polycomb repressive complex 2 (PRC2) catalyzes the methylation of histone H3 lysine 27
(H3K27) and the enrichment of its catalytic product H3K27me3 is responsible for the …

Osteoarthritis (OA) is a joint disease caused by a variety of factors, including aging, obesity
and trauma. MicroRNAs (miRNAs) have been reported to be crucial regulators during OA …

Abstract Neurogenic differentiation factor 1 (NeuroD1) is a transcription factor critical for
promoting neuronal differentiation and maturation. NeuroD1 is involved in neuroblastoma …