[HTML][HTML] The therapeutic effects of saikosaponins on depression through the modulation of neuroplasticity: From molecular mechanisms to potential clinical …

S Chen, K Wang, H Wang, Y Gao, K Nie, X Jiang… - Pharmacological …, 2024 - Elsevier
Depression is a major global health issue that urgently requires innovative and precise
treatment options. In this context, saikosaponin has emerged as a promising candidate …

[HTML][HTML] Ferroptosis: a new view on the prevention and treatment of diabetic kidney disease with traditional Chinese medicine

Y Chen, G Huang, T Qin, Z Zhang, H Wang, Y Xu… - Biomedicine & …, 2024 - Elsevier
Diabetic kidney disease is one of the complications of diabetes mellitus, which can
eventually progress to end-stage kidney disease. The increasing prevalence of diabetic …

The Interplay between Ferroptosis and Neuroinflammation in Central Neurological Disorders

Y Xu, B Jia, J Li, Q Li, C Luo - Antioxidants, 2024 - mdpi.com
Central neurological disorders are significant contributors to morbidity, mortality, and long-
term disability globally in modern society. These encompass neurodegenerative diseases …

Arginine Methylation of β-Catenin Induced by PRMT2 Aggravates LPS-Induced Cognitive Dysfunction and Depression-Like Behaviors by Promoting Ferroptosis

L Mao, J You, M Xie, Y Hu, Q Zhou - Molecular Neurobiology, 2024 - Springer
Depression is a prevalent and debilitating psychiatric disorder, imposing substantial societal
and individual burdens. This study aims to investigate the involvement of ferroptosis and …

[HTML][HTML] Cynaroside improved depressive-like behavior in CUMS mice by suppressing microglial inflammation and ferroptosis

Y Zhou, Y Huang, W Ye, Z Chen, Z Yuan - Biomedicine & Pharmacotherapy, 2024 - Elsevier
Depression is a common mental health disorder, and in recent years, the incidence of
various forms of depression has been on the rise. Most medications for depression are …

Recent advances in neuroinflammation prevention and therapy: the role of natural products and underlying mechanisms based on molecular targets

MM Zhao, JY Duan, Y Shen, Y Liu… - British Journal of …, 2024 - Wiley Online Library
Neuroinflammation is initiated in response to a variety of endogenous and exogenous
sources. As the resident macrophages of the central nervous system, the polarization of …

Stress, pain, anxiety, and depression in endometriosis–Targeting glial activation and inflammation

T Mokhtari, E Irandoost, F Sheikhbahaei - International …, 2024 - Elsevier
Endometriosis (EM) is a gynecological inflammatory disease often accompanied by stress,
chronic pelvic pain (CPP), anxiety, and depression, leading to a diminished quality of life …

Saikosaponins Targeting Programmed Cell Death as Anticancer Agents: Mechanisms and Future Perspectives

X Xiao, C Gao - Drug Design, Development and Therapy, 2024 - Taylor & Francis
Saikosaponins (SS), which are major bioactive compounds in Radix Bupleuri, have long
been used clinically for multicomponent, multitarget, and multipathway therapeutic …

[HTML][HTML] Radix Bupleuri aqueous extract attenuates MK801-induced schizophrenia-like symptoms in mice: Participation of intestinal flora

P Yang, S Huang, Z Luo, S Zhou, C Zhang… - Biomedicine & …, 2024 - Elsevier
Schizophrenia (SCZ) is a psychotic mental disorder characterized by cognitive, behavioral,
and social impairments. However, current pharmacological treatment regimens are subpar …

Deciphering the therapeutic potential of SheXiangXinTongNing: Interplay between gut microbiota and brain metabolomics in a CUMS mice model, with a focus on …

X Wang, J Zhou, T Jiang, J Xu - Phytomedicine, 2024 - Elsevier
Depression, a prevalent and multifaceted mental disorder, has emerged as a significant
public health concern due to its escalating prevalence and heightened risk of severe …