Hallmarks of neurodegenerative diseases
DM Wilson, MR Cookson, L Van Den Bosch… - Cell, 2023 - cell.com
Decades of research have identified genetic factors and biochemical pathways involved in
neurodegenerative diseases (NDDs). We present evidence for the following eight hallmarks …
neurodegenerative diseases (NDDs). We present evidence for the following eight hallmarks …
The amyloid hypothesis in Alzheimer disease: new insights from new therapeutics
E Karran, B De Strooper - Nature Reviews Drug Discovery, 2022 - nature.com
Many drugs that target amyloid-β (Aβ) in Alzheimer disease (AD) have failed to demonstrate
clinical efficacy. However, four anti-Aβ antibodies have been shown to mediate the removal …
clinical efficacy. However, four anti-Aβ antibodies have been shown to mediate the removal …
Biomarker modeling of Alzheimer's disease using PET-based Braak staging
Gold-standard diagnosis of Alzheimer's disease (AD) relies on histopathological staging
systems. Using the topographical information from [18F] MK6240 tau positron-emission …
systems. Using the topographical information from [18F] MK6240 tau positron-emission …
Synergy between amyloid-β and tau in Alzheimer's disease
Patients with Alzheimer's disease (AD) present with both extracellular amyloid-β (Aβ)
plaques and intracellular tau-containing neurofibrillary tangles in the brain. For many years …
plaques and intracellular tau-containing neurofibrillary tangles in the brain. For many years …
An Activity‐Based Fluorescent Probe for Imaging Fluctuations of Peroxynitrite (ONOO−) in the Alzheimer's Disease Brain
P Wang, L Yu, J Gong, J Xiong, S Zi… - Angewandte Chemie …, 2022 - Wiley Online Library
Peroxynitrite (ONOO−) plays a critical role in Alzheimer's disease (AD). To reveal the
ONOO− influx in AD brains, an activatable activity‐based fluorescence probe Rd‐DPA3 was …
ONOO− influx in AD brains, an activatable activity‐based fluorescence probe Rd‐DPA3 was …
Association of short and long sleep duration with amyloid-β burden and cognition in aging
Importance Disrupted sleep is common in aging and is associated with cognition. Age-
related changes to sleep are associated with multiple causes, including early Alzheimer …
related changes to sleep are associated with multiple causes, including early Alzheimer …
The human connectome in Alzheimer disease—relationship to biomarkers and genetics
The pathology of Alzheimer disease (AD) damages structural and functional brain networks,
resulting in cognitive impairment. The results of recent connectomics studies have now …
resulting in cognitive impairment. The results of recent connectomics studies have now …
Alzheimer's disease
JAS Lopez, HM González, GC Léger - Handbook of clinical neurology, 2019 - Elsevier
Alzheimer's disease (AD) dementia refers to a particular onset and course of cognitive and
functional decline associated with age together with a particular neuropathology. It was first …
functional decline associated with age together with a particular neuropathology. It was first …
The multiplex model of the genetics of Alzheimer's disease
Genes play a strong role in Alzheimer's disease (AD), with late-onset AD showing heritability
of 58–79% and early-onset AD showing over 90%. Genetic association provides a robust …
of 58–79% and early-onset AD showing over 90%. Genetic association provides a robust …
Regional Aβ-tau interactions promote onset and acceleration of Alzheimer's disease tau spreading
Amyloid-beta and tau are key molecules in the pathogenesis of Alzheimer's disease, but it
remains unclear how these proteins interact to promote disease. Here, by combining cross …
remains unclear how these proteins interact to promote disease. Here, by combining cross …