Insulin resistance is among the most prevalent endocrine derangements in the world, and it
is closely associated with major diseases of global reach including diabetes mellitus …

Background Nonalcoholic fatty liver disease is associated with hepatic insulin resistance
and type 2 diabetes mellitus. Whether this association has a genetic basis is unknown …

Nonalcoholic fatty liver disease (NAFLD) is now the most frequent chronic liver disease in
Western societies, affecting one in four adults in the USA, and is strongly associated with …

With their ever-growing prevalence, obesity and diabetes represent major health threats of
our society. Based on estimations by the World Health Organization, approximately 300 …

Insulin resistance is defined as a failure of target organs to respond normally to the action of
insulin. Insulin resistance causes incomplete suppression of hepatic glucose output and …

The regulation of body fat stores and blood glucose levels is critical for survival. This review
highlights growing evidence that leptin action in the central nervous system plays a key role …

The insulin resistance syndrome (syndrome X, metabolic syndrome) has become the major
health problem of our times. Associated obesity, dyslipidemia, atherosclerosis, hypertension …

Hormones produced by adipose tissue play a critical role in the regulation of energy intake,
energy expenditure, and lipid and carbohydrate metabolism. This review will address the …

Obesity is a major risk factor for the development of type 2 diabetes, and both conditions are
now recognized to possess significant inflammatory components underlying their …

Recent insights into the neural circuits controlling energy balance and glucose homeostasis
have rekindled the hope for development of novel treatments for obesity and diabetes …