Immunopathology of chronic hepatitis B infection: role of innate and adaptive immune response in disease progression

A Khanam, JV Chua, S Kottilil - International Journal of Molecular …, 2021 - mdpi.com
More than 250 million people are living with chronic hepatitis B despite the availability of
highly effective vaccines and oral antivirals. Although innate and adaptive immune cells play …

Role of platelet cytokines in dengue virus infection

A Singh, P Bisht, S Bhattacharya… - Frontiers in Cellular and …, 2020 - frontiersin.org
Platelets are anucleated blood cells derived from bone marrow megakaryocytes and play a
crucial role in hemostasis and thrombosis. Platelets contain specialized storage organelles …

[HTML][HTML] Cytokines and chemokines in HBV infection

S Zhong, T Zhang, L Tang, Y Li - Frontiers in molecular biosciences, 2021 - frontiersin.org
Chronic hepatitis B virus (HBV) infection remains a leading cause of hepatic inflammation
and damage. The pathogenesis of chronic hepatitis B (CHB) infection is predominantly …

Insights into the impact of hepatitis B virus on hepatic stellate cell activation

H You, X Wang, L Ma, F Zhang, H Zhang… - Cell Communication and …, 2023 - Springer
During chronic hepatitis B virus (HBV) infection, hepatic fibrosis is a serious pathological
condition caused by virus-induced liver damage. The activation of hepatic stellate cells …

The novel small molecule TPN10518 alleviates EAE pathogenesis by inhibiting AP1 to depress Th1/Th17 cell differentiation

L Xie, J Lv, K Saimaier, S Han, M Han, C Wang… - International …, 2023 - Elsevier
Multiple sclerosis (MS) is one of the most common autoimmune diseases of central nervous
system (CNS) demyelination. Experimental autoimmune encephalomyelitis (EAE) is the …

Escherichia coli enhances Th17/Treg imbalance via TLR4/NF-κB signaling pathway in oral lichen planus

J Wang, J Yang, W Xia, M Zhang, H Tang… - International …, 2023 - Elsevier
Oral lichen planus (OLP) is a T-cell-mediated immunoinflammatory disease. Several studies
have proposed that Escherichia coli (E. coli) may participate in the progress of OLP. In this …

CCL17 acts as an antitumor chemokine in micromilieu‐driven immune skewing

Y Li, H Cao, Z Jiang, K Yan, J Shi, S Wang… - International …, 2023 - Elsevier
Background Chemokines are critical players in the local immune responses to tumors.
CCL17 (thymus and activation-regulated chemokine, TARC) and CCL22 (macrophage …

CCR2-overexpressing mesenchymal stem cells targeting damaged liver enhance recovery of acute liver failure

R Xu, B Ni, L Wang, J Shan, L Pan, Y He, G Lv… - Stem Cell Research & …, 2022 - Springer
Background Mesenchymal stem cell (MSC) transplantation is emerging as a promising cell
therapeutic strategy in acute liver failure (ALF) clinical research. The potency of MSCs to …

Role of chemokines and inflammatory cells in respiratory allergy

Y Bao, X Zhu - Journal of Asthma and Allergy, 2022 - Taylor & Francis
The idea of “one airway, one disease” has been gaining importance in the last decade. In
the upper and lower airways, allergic mechanisms interact with each other. In the initial …

Studying T cell responses to hepatotropic viruses in the liver microenvironment

J Lopez-Scarim, SM Nambiar, E Billerbeck - Vaccines, 2023 - mdpi.com
T cells play an important role in the clearance of hepatotropic viruses but may also cause
liver injury and contribute to disease progression in chronic hepatitis B and C virus infections …