Imputation-based meta-analysis of severe malaria in three African populations
Combining data from genome-wide association studies (GWAS) conducted at different
locations, using genotype imputation and fixed-effects meta-analysis, has been a powerful …
locations, using genotype imputation and fixed-effects meta-analysis, has been a powerful …
Genetic variants associated with the white blood cell count in 13,923 subjects in the eMERGE Network
White blood cell count (WBC) is unique among identified inflammatory predictors of chronic
disease in that it is routinely measured in asymptomatic patients in the course of routine …
disease in that it is routinely measured in asymptomatic patients in the course of routine …
Diagnosis of iron-deficient states
NM Archer, C Brugnara - Critical reviews in clinical laboratory …, 2015 - Taylor & Francis
The diagnosis of iron deficiency anemia is typically straightforward, especially when classic
biochemical and hematological changes are present in a subject at risk. It can be …
biochemical and hematological changes are present in a subject at risk. It can be …
Identification of CAD candidate genes in GWAS loci and their expression in vascular cells [S]
A Erbilgin, M Civelek, CE Romanoski, C Pan… - Journal of lipid …, 2013 - ASBMB
Recent genome-wide association studies (GWAS) have identified 35 loci that significantly
associate with coronary artery disease (CAD) susceptibility. The majority of the genes …
associate with coronary artery disease (CAD) susceptibility. The majority of the genes …
SNPs associated with cerebrospinal fluid phospho-tau levels influence rate of decline in Alzheimer's disease
C Cruchaga, JSK Kauwe, K Mayo, N Spiegel… - PLoS …, 2010 - journals.plos.org
Alzheimer's Disease (AD) is a complex and multifactorial disease. While large genome-wide
association studies have had some success in identifying novel genetic risk factors for AD …
association studies have had some success in identifying novel genetic risk factors for AD …
A meta-analysis and genome-wide association study of platelet count and mean platelet volume in african americans
Several genetic variants associated with platelet count and mean platelet volume (MPV)
were recently reported in people of European ancestry. In this meta-analysis of 7 genome …
were recently reported in people of European ancestry. In this meta-analysis of 7 genome …
A Single Nucleotide Polymorphism in SH2B3/LNK Promotes Hypertension Development and Renal Damage
MR Alexander, S Hank, BL Dale, L Himmel… - Circulation …, 2022 - Am Heart Assoc
Background: SH2B3 (SH2B adaptor protein 3) is an adaptor protein that negatively
regulates cytokine signaling and cell proliferation. A common missense single nucleotide …
regulates cytokine signaling and cell proliferation. A common missense single nucleotide …
Beyond ubiquitination: the atypical functions of Fbxo7 and other F-box proteins
DE Nelson, SJ Randle, H Laman - Open biology, 2013 - royalsocietypublishing.org
F-box proteins (FBPs) are substrate-recruiting subunits of Skp1-cullin1-FBP (SCF)-type E3
ubiquitin ligases. To date, 69 FBPs have been identified in humans, but ubiquitinated …
ubiquitin ligases. To date, 69 FBPs have been identified in humans, but ubiquitinated …
Iron-refractory iron deficiency anemia (IRIDA)
MM Heeney, KE Finberg - Hematology/Oncology Clinics, 2014 - hemonc.theclinics.com
Iron is an essential metal for many biologic processes in mammals. Its primary role is to bind
oxygen in the heme moiety of hemoglobin. Iron also plays a central role in the enzymatic …
oxygen in the heme moiety of hemoglobin. Iron also plays a central role in the enzymatic …
Iron deficiency in pulmonary arterial hypertension: a potential therapeutic target
Iron deficiency is known to be common and detrimental in chronic left heart failure, where
parenteral iron treatment has been shown to improve exercise capacity, New York Heart …
parenteral iron treatment has been shown to improve exercise capacity, New York Heart …