Since its inception in 1995, the biopharmaceutical classification system (BCS) has become
an increasingly important tool for regulation of drug products world-wide. Until now …

Formulations play a key role in assessing the biological properties of a molecule during drug
discovery. Maximising exposure is the primary objective in early animal experimentation, so …

Before being absorbed in the small intestine and/or colon, orally administered drugs
inevitably need to pass through the stomach. Hence, it seems reasonable that the residence …

Gastric pH levels were measured in samples of gastric aspirates from eight fasted beagle
dogs. The gastric pH in fasting dogs fluctuated from 2.7 to 8.3, with a mean of 6.8±0.2 (SE) …

In preclinical research, Beagle dogs are an important model for formulation development
and for evaluation of food effects on drug absorption. In this study, the gastrointestinal transit …

No Heading Purpose. The aim of this research was to develop a pH-dependent canine
absorption model for studying pH effect on both dissolution in vitro and pharmacokinetics in …

Currently available anti-HIV drugs can be classified into three categories: nucleoside
analogue reverse transcriptase inhibitors, non-nucleoside reverse transcriptase inhibitors …

Orally administered anti-HIV drugs must be adequately and consistently absorbed for
therapy to be successful. This review discusses the barriers to achieving oral bioavailability …

ABSTRACT A preclinical canine model capable of predicting a compound's potential for a
human food effect was developed. The beagle dog was chosen as the in vivo model. A …

Many pharmaceutically active compounds are weak electrolytes and are ionizable in the pH
range experienced throughout the gastrointestinal tract. Changes in protonation state due to …