FTY720 ameliorates renal fibrosis by simultaneously affecting leucocyte recruitment and TGF-β signalling in fibroblasts
T Tian, J Zhang, X Zhu, S Wen, D Shi… - Clinical & Experimental …, 2017 - academic.oup.com
Renal fibrosis is the common final manifestation of chronic kidney diseases and usually
results in end-stage renal failure. In this study, we evaluated the effect of fingolimod …
results in end-stage renal failure. In this study, we evaluated the effect of fingolimod …
Chemical tools for studying lipid-binding class AG protein–coupled receptors
Cannabinoid, free fatty acid, lysophosphatidic acid, sphingosine 1-phosphate, prostanoid,
leukotriene, bile acid, and platelet-activating factor receptor families are class AG protein …
leukotriene, bile acid, and platelet-activating factor receptor families are class AG protein …
The double-edge role of B cells in mediating antitumor T-cell immunity: Pharmacological strategies for cancer immunotherapy
JZ Wang, YH Zhang, XH Guo, HY Zhang… - International …, 2016 - Elsevier
Emerging evidence reveals the controversial role of B cells in antitumor immunity, but the
underlying mechanisms have to be explored. Three latest articles published in the issue 521 …
underlying mechanisms have to be explored. Three latest articles published in the issue 521 …
[HTML][HTML] Expression of functional sphingosine-1 phosphate receptor-1 is reduced by B cell receptor signaling and increased by inhibition of PI3 kinase δ but not SYK or …
KJ Till, AR Pettitt, JR Slupsky - The Journal of Immunology, 2015 - journals.aai.org
BCR signaling pathway inhibitors such as ibrutinib, idelalisib, and fostamatinib (respective
inhibitors of Bruton's tyrosine kinase, PI3Kδ, and spleen tyrosine kinase) represent a …
inhibitors of Bruton's tyrosine kinase, PI3Kδ, and spleen tyrosine kinase) represent a …
Differential effects of selective versus unselective sphingosine 1-phosphate receptor modulators on T-and B-cell response to SARS-CoV-2 vaccination
U Proschmann, M Mueller-Enz… - Multiple Sclerosis …, 2023 - journals.sagepub.com
Background: Sphingosine 1-phosphat receptor modulators (S1PRMs) have been linked to
attenuated immune response to SARS-CoV-2 vaccines. Objective: To characterize …
attenuated immune response to SARS-CoV-2 vaccines. Objective: To characterize …
S1PR4 is required for plasmacytoid dendritic cell differentiation
C Dillmann, J Mora, C Olesch, B Brüne… - Biological …, 2015 - degruyter.com
Abstract The sphingolipid sphingosine-1-phosphate (S1P) has various functions in immune
cell biology, regulating survival, proliferation, and, most prominently, migration. S1P couples …
cell biology, regulating survival, proliferation, and, most prominently, migration. S1P couples …
[HTML][HTML] BAFFR activates PI3K/AKT signaling in human naive but not in switched memory B cells through direct interactions with B cell antigen receptors
E Sevdali, V Block, M Lataretu, H Li, CR Smulski… - Cell reports, 2022 - cell.com
Binding of BAFF to BAFFR activates in mature B cells PI3K/AKT signaling regulating protein
synthesis, metabolic fitness, and survival. In humans, naive and memory B cells express the …
synthesis, metabolic fitness, and survival. In humans, naive and memory B cells express the …
The emerging alliance of sphingosine‐1‐phosphate signalling and immune cells: from basic mechanisms to implications in hypertension
N Don‐Doncow, Y Zhang, H Matuskova… - British Journal of …, 2019 - Wiley Online Library
The immune system plays a considerable role in hypertension. In particular, T‐lymphocytes
are recognized as important players in its pathogenesis. Despite substantial experimental …
are recognized as important players in its pathogenesis. Despite substantial experimental …
[HTML][HTML] Circulating sphingosine-1-phosphate as a prognostic biomarker for community-acquired pneumonia
SC Hsu, JH Chang, YP Hsu, KJ Bai, SK Huang… - PLoS …, 2019 - journals.plos.org
Early determination of the severity of Community-Acquired Pneumonia (CAP) is essential for
better disease prognosis. Current predictors are suboptimal, and their clinical utility remains …
better disease prognosis. Current predictors are suboptimal, and their clinical utility remains …
Design, Synthesis, and In Vitro and In Vivo Evaluation of an 18F-Labeled Sphingosine 1-Phosphate Receptor 1 (S1P1) PET Tracer
Sphingosine 1-phosphate receptor 1 (S1P1) plays a pivotal signaling role in inflammatory
response; because S1P1 modulation has been identified as a therapeutic target for various …
response; because S1P1 modulation has been identified as a therapeutic target for various …