[HTML][HTML] Molecular pathways involved in COVID-19 and potential pathway-based therapeutic targets

M Farahani, Z Niknam, LM Amirabad… - Biomedicine & …, 2022 - Elsevier
Deciphering the molecular downstream consequences of severe acute respiratory
syndrome coronavirus (SARS-CoV)− 2 infection is important for a greater understanding of …

Targeting SARS-CoV-2 entry processes: The promising potential and future of host-targeted small-molecule inhibitors

A Wu, K Shi, J Wang, R Zhang, Y Wang - European Journal of Medicinal …, 2024 - Elsevier
The COVID-19 pandemic, caused by SARS-CoV-2, has had a huge impact on global health.
To respond to rapidly mutating viruses and to prepare for the next pandemic, there is an …

SARS-CoV-2 vaccination and myocarditis or myopericarditis: population based cohort study

A Husby, JV Hansen, E Fosbøl, EM Thiesson… - bmj, 2021 - bmj.com
Objective To investigate the association between SARS-CoV-2 vaccination and myocarditis
or myopericarditis. Design Population based cohort study. Setting Denmark. Participants 4 …

[HTML][HTML] Circulating ACE2 activity predicts mortality and disease severity in hospitalized COVID-19 patients

M Fagyas, Z Fejes, R Sütő, Z Nagy, B Székely… - International Journal of …, 2022 - Elsevier
Objectives Angiotensin-converting enzyme 2 (ACE2) represents the primary receptor for
SARS-CoV-2 to enter endothelial cells. Here we investigated circulating ACE2 activity to …

GP consultation rates for sequelae after acute covid-19 in patients managed in the community or hospital in the UK: population based study

HR Whittaker, C Gulea, A Koteci, C Kallis, AD Morgan… - bmj, 2021 - bmj.com
Objectives To describe the rates for consulting a general practitioner (GP) for sequelae after
acute covid-19 in patients admitted to hospital with covid-19 and those managed in the …

Quantifying renin-angiotensin-system alterations in COVID-19

F Pucci, F Annoni, RAS Dos Santos, FS Taccone… - Cells, 2021 - mdpi.com
The renin-angiotensin system (RAS) plays a pivotal role in a wide series of physiological
processes, among which inflammation and blood pressure regulation. One of its key …

Molecular mechanisms of endothelialitis in SARS-CoV-2 infection: Evidence for VE-cadherin cleavage by ACE2

L Bouillet, A Deroux, M Benmarce, C Guérin… - International Journal of …, 2023 - mdpi.com
Long COVID-19 syndrome appears after Severe Acute Respiratory Syndrome-Corona Virus
(SARS-CoV-2) infection with acute damage to microcapillaries, microthrombi, and …

JG26 attenuates ADAM17 metalloproteinase-mediated ACE2 receptor processing and SARS-CoV-2 infection in vitro

V Gentili, S Beltrami, D Cuffaro, G Cianci, G Maini… - Pharmacological …, 2024 - Springer
Background ADAM17 is a metalloprotease implicated in the proteolysis of angiotensin-
converting enzyme 2 (ACE2), known to play a critical role in the entry and spread of SARS …

[HTML][HTML] Circulating ACE2 level and zinc/albumin ratio as potential biomarkers for a precision medicine approach to COVID-19

S Benedetti, D Sisti, D Vandini, S Barocci… - Advances in Biological …, 2023 - Elsevier
Highly mutable influenza is successfully countered based on individual susceptibility and
similar precision-like medicine approach should be effective against SARS-COV-2. Among …

Modulations of Homeostatic ACE2, CD147, GRP78 Pathways Correlate with Vascular and Endothelial Performance Markers during Pulmonary SARS-CoV-2 Infection

A Nisa, R Kumar, S Ramasamy, A Kolloli, J Olejnik… - Cells, 2024 - mdpi.com
The pathologic consequences of Coronavirus Disease-2019 (COVID-19) include elevated
inflammation and dysregulated vascular functions associated with thrombosis. In general …