Emerging role of exosomes in cancer progression and tumor microenvironment remodeling

MDA Paskeh, M Entezari, S Mirzaei, A Zabolian… - Journal of hematology & …, 2022 - Springer
Cancer is one of the leading causes of death worldwide, and the factors responsible for its
progression need to be elucidated. Exosomes are structures with an average size of 100 nm …

[HTML][HTML] The tumor microenvironment: a milieu hindering and obstructing antitumor immune responses

A Labani-Motlagh, M Ashja-Mahdavi… - Frontiers in …, 2020 - frontiersin.org
The success of cancer immunotherapy relies on the knowledge of the tumor
microenvironment and the immune evasion mechanisms in which the tumor, stroma, and …

Transport of extracellular vesicles across the blood-brain barrier: brain pharmacokinetics and effects of inflammation

WA Banks, P Sharma, KM Bullock, KM Hansen… - International journal of …, 2020 - mdpi.com
Extracellular vesicles can cross the blood–brain barrier (BBB), but little is known about
passage. Here, we used multiple-time regression analysis to examine the ability of 10 …

Exosomes: composition, biogenesis, and mechanisms in cancer metastasis and drug resistance

L Mashouri, H Yousefi, AR Aref, A Ahadi, F Molaei… - Molecular cancer, 2019 - Springer
Tumor-derived exosomes (TDEs) participate in formation and progression of different cancer
processes, including tumor microenvironment (TME) remodeling, angiogenesis, invasion …

Challenges in exosome isolation and analysis in health and disease

N Ludwig, TL Whiteside, TE Reichert - International journal of molecular …, 2019 - mdpi.com
A growing body of evidence emphasizes the important role exosomes in different
physiological and pathological conditions. Exosomes, virus-size extracellular vesicles (EVs) …

Exosomes in angiogenesis and anti-angiogenic therapy in cancers

W Olejarz, G Kubiak-Tomaszewska… - International journal of …, 2020 - mdpi.com
Angiogenesis is the process through which new blood vessels are formed from pre-existing
ones. Exosomes are involved in angiogenesis in cancer progression by transporting …

[HTML][HTML] The biology, function, and applications of exosomes in cancer

J Liu, L Ren, S Li, W Li, X Zheng, Y Yang, W Fu… - … Pharmaceutica Sinica B, 2021 - Elsevier
Exosomes are cell-derived nanovesicles with diameters from 30 to 150 nm, released upon
fusion of multivesicular bodies with the cell surface. They can transport nucleic acids …

Extracellular vesicles in the tumor microenvironment: old stories, but new tales

L Han, EWF Lam, Y Sun - Molecular cancer, 2019 - Springer
Mammalian cells synthesize and release heterogeneous extracellular vesicles (EVs) which
can be generally recognized as subclasses including exosomes, microvesicles (MVs), and …

Tumor microenvironment: an evil nexus promoting aggressive head and neck squamous cell carcinoma and avenue for targeted therapy

AA Bhat, P Yousuf, NA Wani, A Rizwan… - Signal transduction and …, 2021 - nature.com
Head and neck squamous cell carcinoma (HNSCC) is a very aggressive disease with a poor
prognosis for advanced-stage tumors. Recent clinical, genomic, and cellular studies have …

Exosome-mediated remodeling of the tumor microenvironment: from local to distant intercellular communication

Y Huang, M Kanada, J Ye, Y Deng, Q He, Z Lei… - Cancer Letters, 2022 - Elsevier
Extracellular vesicles (EVs) are membrane-enveloped nanoscale particles that carry various
bioactive signaling molecules secreted by cells. Their biological roles depend on the …