Ischaemia reperfusion injury in liver transplantation: Cellular and molecular mechanisms

WA Dar, E Sullivan, JS Bynon, H Eltzschig… - Liver …, 2019 - Wiley Online Library
Liver disease causing end organ failure is a growing cause of mortality. In most cases, the
only therapy is liver transplantation. However, liver transplantation is a complex undertaking …

[HTML][HTML] Role of immuno-inflammatory signals in liver ischemia-reperfusion injury

C Kaltenmeier, R Wang, B Popp, D Geller, S Tohme… - Cells, 2022 - mdpi.com
Ischemia reperfusion injury (IRI) is a major obstacle in liver resection and liver
transplantation. The initial step of IRI is mediated through ischemia which promotes the …

Dual-responsive biohybrid neutrobots for active target delivery

H Zhang, Z Li, C Gao, X Fan, Y Pang, T Li, Z Wu… - Science Robotics, 2021 - science.org
Swimming biohybrid microsized robots (eg, bacteria-or sperm-driven microrobots) with self-
propelling and navigating capabilities have become an exciting field of research, thanks to …

[HTML][HTML] The role of cytokines in neutrophil development, tissue homing, function and plasticity in health and disease

M Tsioumpekou, D Krijgsman, JHW Leusen… - Cells, 2023 - mdpi.com
Neutrophils are crucial innate immune cells and comprise 50–70% of the white blood cell
population under homeostatic conditions. Upon infection and in cancer, blood neutrophil …

Regulation and functional roles of chemokines in liver diseases

S Cao, M Liu, TS Sehrawat, VH Shah - Nature reviews Gastroenterology …, 2021 - nature.com
Inflammation is a major contributor to the pathogenesis of almost all liver diseases. Low-
molecular-weight proteins called chemokines are the main drivers of liver infiltration by …

The evolving role of liver sinusoidal endothelial cells in liver health and disease

MJ McConnell, E Kostallari, SH Ibrahim, Y Iwakiri - Hepatology, 2023 - journals.lww.com
LSECs are a unique population of endothelial cells within the liver and are recognized as
key regulators of liver homeostasis. LSECs also play a key role in liver disease, as …

[HTML][HTML] The roles of neutrophils in the pathogenesis of liver diseases

J Tang, Z Yan, Q Feng, L Yu, H Wang - Frontiers in Immunology, 2021 - frontiersin.org
Neutrophils are the largest population of circulating leukocytes and the first responder
against invading pathogens or other danger signals. Sophisticated machineries help them …

[HTML][HTML] Ferroptosis—a new dawn in the treatment of organ ischemia–reperfusion injury

L Zhou, S Han, J Guo, T Qiu, J Zhou, L Shen - Cells, 2022 - mdpi.com
Ischemia–reperfusion (I/R) is a common pathological phenomenon that occurs in numerous
organs and diseases. It generally results from secondary damage caused by the recovery of …

[HTML][HTML] Immune-mediated drug-induced liver injury: immunogenetics and experimental models

A Gerussi, A Natalini, F Antonangeli… - International Journal of …, 2021 - mdpi.com
Drug-induced liver injury (DILI) is a challenging clinical event in medicine, particularly
because of its ability to present with a variety of phenotypes including that of autoimmune …

[HTML][HTML] Targeting oxidative stress with polyphenols to fight liver diseases

IF Machado, RG Miranda, DJ Dorta, AP Rolo… - Antioxidants, 2023 - mdpi.com
Reactive oxygen species (ROS) are important second messengers in many metabolic
processes and signaling pathways. Disruption of the balance between ROS generation and …