An understanding of the neurobiological correlates of vulnerability to psychosis is
fundamental to research on schizophrenia. We systematically reviewed data from studies …

Cognitive deficits are critical determinants of schizophrenia morbidity. In this review, we offer
a mechanistic perspective regarding schizophrenia-related changes observed in prefrontal …

Although there is considerable evidence that patients with schizophrenia fail to activate the
dorsolateral prefrontal cortex (DLPFC) to the degree seen in normal comparison subjects …

OBJECTIVE: Numerous neuroimaging studies have examined the function of the
dorsolateral prefrontal cortex in schizophrenia; although abnormalities usually are identified …

Background Dysfunction of frontal-striatal, particularly orbitofrontal-striatal, circuitry has been
implicated in the pathophysiology of obsessive-compulsive disorder (OCD), characterized …

Abstract Background: The Functional Imaging Biomedical Informatics Network is a
consortium developing methods for multisite functional imaging studies. Both prefrontal …

Impaired working memory (WM) function in schizophrenia has been associated with
abnormal activation of the dorsolateral prefrontal cortex (DLPFC). It is, however, not clear …

OBJECTIVE: The dorsolateral prefrontal cortex and the anterior cingulate cortex are critical
components of the brain circuitry underlying executive control. The objective of this study …

Context It remains unclear whether altered regional brain physiological activity in patients
with schizophrenia during working memory tasks relates to maintenance-related processes …

To test competing models of age-related changes in brain functioning (capacity limitation,
neural efficiency, compensatory reorganization, and dedifferentiation), young (n= 40; mean …