Cardiac arrhythmias are among the leading causes of mortality. They often arise from
alterations in the electrophysiological properties of cardiac cells and their underlying ionic …

Intermediate filaments are major components of the cytoskeleton. Desmin and synemin,
cytoplasmic intermediate filament proteins and A-type lamins, nuclear intermediate filament …

One life-threatening outcome of cardiovascular disease is myocardial infarction, where
cardiomyocytes are deprived of oxygen. To study inter-individual differences in response to …

Although historically, the traditional bidimensional in vitro cell system has been widely used
in research, providing much fundamental information regarding cellular functions and …

Restrictive cardiomyopathy (RCM), a potentially devastating heart muscle disorder, is
characterized by diastolic dysfunction due to abnormal muscle relaxation and myocardial …

Arrhythmogenic cardiomyopathy has been clinically defined since the 1980s and causes
right or biventricular cardiomyopathy associated with ventricular arrhythmia. Although it is a …

Cardiomyopathies (CMPs) represent a significant healthcare burden and are a major cause
of heart failure leading to premature death. Several CMPs are now recognized to have a …

Mutations in RBM20 encoding the RNA‐binding motif protein 20 (RBM20) are associated
with an early onset and clinically severe forms of cardiomyopathies. Transcriptome analyses …

Stem cells are undifferentiated cells that can self-renew and differentiate into diverse types
of mature and functional cells while maintaining their original identity. This profound …

A major cause of heart failure is cardiomyopathies, with dilated cardiomyopathy (DCM) as
the most common form. Over 40 genes are linked to DCM, among them TTN and RBM20 …