Chronic pain affects a large part of the population causing functional disability, being often
associated with coexisting psychological disorders, such as depression and anxiety …

Lysophospholipids, exemplified by lysophosphatidic acid (LPA) and sphingosine 1-
phosphate (S1P), are produced by the metabolism and perturbation of biological …

Among the phospholipase A2 (PLA2) superfamily, which typically catalyzes the sn‐2
hydrolysis of phospholipids to yield fatty acids and lysophospholipids, the secreted PLA2 …

The detection of environmental temperatures is critical for survival, yet inappropriate
responses to thermal stimuli can have a negative impact on overall health. The physiological …

Lysophosphatidic acid (LPA) plays a critical role in developing and maintaining chronic pain
in various animal models. Previous studies have reported that cytosolic and calcium …

Phospholipase D (PLD) is an enzyme that consists of six isoforms (PLD1–PLD6) and has
been discovered in different organisms including bacteria, viruses, plants, and mammals …

Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a severe adverse
reaction to chemotherapeutics, which seriously affects the outcome of chemotherapy and …

Purpose Lysophosphatidic acid (LPA) is a bioactive molecule which participates in many
physical and pathological processes. Although LPA receptor 6 (LPAR6), the last identified …

Pain signals are relayed to the brain via a nociceptive system, and in rare cases, this
nociceptive system contains genetic variants that can limit the pain response. Here, we …

We report that the neurotrophin receptor p75 contributes to sensory neuron survival through
the regulation of cholesterol metabolism in Schwann cells. Selective deletion of p75 in …