Molecular mechanisms of kidney injury and repair
S Rayego-Mateos, L Marquez-Expósito… - International journal of …, 2022 - mdpi.com
Chronic kidney disease (CKD) will become the fifth global cause of death by 2040, thus
emphasizing the need to better understand the molecular mechanisms of damage and …
emphasizing the need to better understand the molecular mechanisms of damage and …
Clinical implication of phosphodiesterase-4-inhibition
MA Schick, N Schlegel - International Journal of Molecular Sciences, 2022 - mdpi.com
The pleiotropic function of 3′, 5′-cyclic adenosine monophosphate (cAMP)-dependent
pathways in health and disease led to the development of pharmacological …
pathways in health and disease led to the development of pharmacological …
A therapeutic perspective of HDAC8 in different diseases: an overview of selective inhibitors
Histone deacetylases (HDACs) are epigenetic enzymes which participate in transcriptional
repression and chromatin condensation mechanisms by removing the acetyl moiety from …
repression and chromatin condensation mechanisms by removing the acetyl moiety from …
[HTML][HTML] Epithelial-mesenchymal transition in age-associated thymic involution: mechanisms and therapeutic implications
J Yang, J Liu, J Liang, F Li, W Wang, H Chen… - Ageing research reviews, 2023 - Elsevier
The thymus is a critical immune organ with endocrine and immune functions that plays
important roles in the physiological and pathological processes of the body. However, with …
important roles in the physiological and pathological processes of the body. However, with …
Hypoxic mesenchymal stem cell-derived extracellular vesicles ameliorate renal fibrosis after ischemia–reperfusion injure by restoring CPT1A mediated fatty acid …
Z Gao, C Zhang, F Peng, Q Chen, Y Zhao… - Stem Cell Research & …, 2022 - Springer
Background Renal fibrosis is a common pathological process of chronic kidney diseases
induced by multiple factors. Hypoxic pretreatment of mesenchymal stem cells can enhance …
induced by multiple factors. Hypoxic pretreatment of mesenchymal stem cells can enhance …
A review of medicinal plants with renoprotective activity in diabetic nephropathy animal models
Diabetic nephropathy (DN), also recognized as diabetic kidney disease, is a kidney
malfunction caused by diabetes mellitus. A possible contributing factor to the onset of DN is …
malfunction caused by diabetes mellitus. A possible contributing factor to the onset of DN is …
Metabolic dysfunction in the regulation of the NLRP3 inflammasome activation: A potential target for diabetic nephropathy
W Zhao, L Zhou, P Novák, X Shi, CB Lin… - Journal of Diabetes …, 2022 - Wiley Online Library
Metabolic dysfunction plays a key role in the development of diabetic nephropathy (DN).
However, the exact effects and mechanisms are still unclear. The pyrin domain‐containing …
However, the exact effects and mechanisms are still unclear. The pyrin domain‐containing …
Rosmarinic acid ameliorates renal interstitial fibrosis by inhibiting the phosphorylated-AKT mediated epithelial–mesenchymal transition in vitro and in vivo
YH Hsieh, JP Tsai, YH Ting, TW Hung, WW Chao - Food & Function, 2022 - pubs.rsc.org
Indoxyl sulfate (IS), a uremic toxin, causes chronic kidney disease (CKD) progression via
renal fibrosis. Epithelial–mesenchymal transition (EMT) is a crucial feature of renal fibrosis …
renal fibrosis. Epithelial–mesenchymal transition (EMT) is a crucial feature of renal fibrosis …
Research Progress of Cordyceps sinensis and Its Fermented Mycelium Products on Ameliorating Renal Fibrosis by Reducing Epithelial-to-Mesenchymal Transition
Y Zhang, K Li, C Zhang, H Liao, R Li - Journal of Inflammation …, 2023 - Taylor & Francis
Renal fibrosis is a hallmark and common outcome of various chronic kidney diseases
(CKDs) and manifests pathologically as accumulation and deposition of extracellular matrix …
(CKDs) and manifests pathologically as accumulation and deposition of extracellular matrix …
Sodium–glucose cotransporter inhibitors and kidney fibrosis: review of the current evidence and related mechanisms
Sodium–glucose cotransporter inhibitors (SGLT2i) are a new class of anti-diabetic drugs that
have beneficial cardiovascular and renal effects. These drugs decrease proximal tubular …
have beneficial cardiovascular and renal effects. These drugs decrease proximal tubular …