The prevalence of obesity has dramatically increased in recent years and now includes a
significant proportion of the world's children, adolescents and adults. Obesity is linked to a …

The prevalence of obesity in adults and children is rapidly increasing across the world.
Several general (patho) physiological alterations associated with obesity have been …

Introduction: Obesity is associated with many physiological changes. We review available
evidence regarding five commonly accepted assumptions to a priori predict the impact of …

The prevalence of significant obesity continues to rise in both developed and developing
countries, and is associated with an increased incidence of a wide spectrum of medical and …

There is mounting evidence to suggest that lean body mass (LBM) may be a better predictor
of drug dosage than either total bodyweight (TBW) or body surface area (BSA), although the …

Background Remifentanil is a short-acting opioid whose pharmacokinetics have been
characterized in detail. However, the impact of obesity on remifentanil pharmacokinetics has …

Introduction Obesity is associated with many physiological changes. We review available
evidence regarding five commonly accepted assumptions to a priori predict the impact of …

Obesity is a pathophysiological state defined by a body mass index> 30 kg/m 2 and
characterized by an adipose tissue accumulation leading to an important weight increased …

Aims For a given passively‐distributed lipophilic drug, the extent of in vivo distribution
(pharmacokinetic volume of distribution, Vd) in obese individuals increases in relation to the …

The effects of diabetes mellitus on the pharmacokinetics and pharmacodynamics of drugs
have been well described in experimental animal models; however, only minimal data exist …