In recent years, a number of studies focused on the role of epigenetics, including DNA
methylation, in spermatogenesis and male infertility. We aimed to provide an overview of the …

The evolutionary theory of aging supports a trade-off relationship between reproduction and
aging. Aging of the male reproductive system primarily affects the testes, leading to a …

Aging men display reduced reproductive health; however, testis aging is poorly understood
at the molecular and genomic levels. Here, we utilized single-cell RNA-seq to profile over …

Normal spermatogenesis and sperm function are crucial for male fertility. The effects of
healthy testicular aging and testicular premature aging on spermatogenesis, sperm function …

Glutathione synthetase (GSS) catalyzes the final step in the synthesis of glutathione (GSH),
a well-established antioxidant. Research on the specific roles of the Gss gene during …

Male infertility accounts for nearly 40%–50% of all infertile cases. One of the most prevalent
disorders detected in infertile men is errors in the MEST differentially methylated region …

N6-methyladenosine (m6A) is the most prevalent reversible RNA modification in the
mammalian transcriptome. It has recently been demonstrated that m6A is crucial for male …

Background The scientific and clinical communities now recognize that sperm DNA integrity
is crucial for successful fertilization, good embryo development, and offspring quality of life …

Background Sperm DNA integrity is increasingly seen as a critical characteristic determining
reproductive success, both in natural reproduction and in assisted reproductive technologies …

In this study, the semen parameters, sperm chromatin integrity, antioxidant enzyme levels,
and reproductive hormone levels of subfertile male subjects from Pakistan were assessed in …