Hemorrhagic transformation (HT) is a common complication in patients with acute ischemic
stroke. It occurs when peripheral blood extravasates across a disrupted blood brain barrier …

Despite recent developments in innovative treatment strategies, stroke remains one of the
leading causes of death and disability worldwide. Stem cell therapy is currently attracting …

While the mainstay of acute stroke treatment includes revascularization via recombinant
tissue plasminogen activator or mechanical thrombectomy, only a minority of stroke patients …

Peroxisome proliferator-activated receptor γ (PPARγ) is a widely expressed ligand-
modulated transcription factor that governs the expression of genes involved in …

The present study was designed to follow neuroinflammation after ischemic brain injury in
the long-term survival rat model. Immunohistochemistry was performed 2 years after 10 min …

Andrographis paniculata has long been part of the traditional herbal medicine system in
Asia and in Scandinavia. Andrographolide was isolated as a major bioactive constituent of …

Abstract Background Stroke affects 3–4% of adults and kills numerous people each year.
Recovering blood flow with minimal reperfusion-induced injury is crucial. However, the …

Ruscogenin, an important steroid sapogenin derived from Ophiopogon japonicus, has been
shown to inhibit cerebral ischemic injury. However, its potential molecular action on blood …

Ischemic cerebral infarction represents a significant cause of disability and death worldwide.
Caspase-1 is activated by the NLRP3/ASC pathway and inflammasomes, thus triggering …

Background: Ischemic stroke is a devastating disease that causes long-term disability.
However, its pathogenesis is unclear, and treatments for ischemic stroke are limited. Recent …