Despite the well-known sex dimorphism in cardiovascular disease traits, the exact genetic,
molecular, and cellular underpinnings of these differences are not well understood. A …

Epigenomic profiling has enabled large-scale identification of regulatory elements, yet we
still lack a systematic mapping from any sequence or variant to regulatory activities. We …

The Niemann–Pick C1-like 1 (NPC1L1) protein is a cholesterol transporter that is expressed
in the small intestine. This report describes the discovery of NPC1L1, its transport properties …

Large-scale genomic and transcriptomic initiatives offer unprecedented insight into complex
traits, but clinical translation remains limited by variant-level associations without biological …

Importance People with major psychiatric disorders (MPDs) have a 10-to 20-year shorter life
span than the rest of the population, and this difference is mainly due to comorbid …

Background Familial chylomicronemia syndrome (FCS) is an ultra-rare phenotype that is
usually caused by biallelic mutations in the LPL gene encoding lipoprotein lipase, or less …

Background and aims Evinacumab, an angiopoietin-like protein 3 monoclonal antibody,
reduced low-density lipoprotein cholesterol (LDL-C) significantly in a Phase 2 study of …

Background Obesity and dyslipidemias are risk factors for developing cardiovascular
diseases, the leading causes of morbidity and mortality worldwide. The pathogenesis of …

Aims To identify the most effective dietary pattern for improving cardiovascular risk factors in
people with type 2 diabetes. Methods PubMed, Embase, the Cochrane library, SCOPUS and …

Copy number variants (CNVs) are a type of genetic polymorphism which contribute to
phenotypic variation in several species, including livestock. In this study, we used genomic …