Cell and cytokine imbalances in rheumatoid synovitis

MC Boissier - Joint Bone Spine, 2011 - Elsevier
Rheumatoid synovitis is a complex process in which systemic and local homeostatic
dysregulation is expressed in the joint. The main genetic susceptibility factors are HLA …

[HTML][HTML] Cytokines in chronic rheumatic diseases: is everything lack of homeostatic balance?

C Chizzolini, JM Dayer, P Miossec - Arthritis research & therapy, 2009 - Springer
Biological systems have powerful inbuilt mechanisms of control intended to maintain
homeostasis. Cytokines are no exception to this rule, and imbalance in cytokine activities …

[HTML][HTML] Protein expression profiling of inflammatory mediators in human temporal lobe epilepsy reveals co-activation of multiple chemokines and cytokines

AA Kan, W de Jager, M de Wit, C Heijnen… - Journal of …, 2012 - Springer
Mesial temporal lobe epilepsy (mTLE) is a chronic and often treatment-refractory brain
disorder characterized by recurrent seizures originating from the hippocampus. The …

Production of IL‐27 in multiple sclerosis lesions by astrocytes and myeloid cells: modulation of local immune responses

V Sénécal, G Deblois, D Beauseigle, R Schneider… - Glia, 2016 - Wiley Online Library
The mechanisms whereby human glial cells modulate local immune responses are not fully
understood. Interleukin‐27 (IL‐27), a pleiotropic cytokine, has been shown to dampen the …

[HTML][HTML] IL-27-induced type 1 regulatory T-cells produce oxysterols that constrain IL-10 production

S Vigne, F Chalmin, D Duc, AS Clottu… - Frontiers in …, 2017 - frontiersin.org
The behaviors of lymphocytes, including CD4+ T helper cells, are controlled on many levels
by internal metabolic properties. Lipid metabolites have recently been ascribed a novel …

Evaluating the potential of IL-27 as a novel therapeutic agent in HIV-1 infection

S Swaminathan, L Dai, HC Lane, T Imamichi - Cytokine & growth factor …, 2013 - Elsevier
Abstract Interleukin 27 (IL-27) is an immunomodulatory cytokine with important roles in both
the innate and adaptive immune systems. In the last five years, the addition of exogenous IL …

[HTML][HTML] Causal associations between circulating cytokines and risk of sepsis and related outcomes: a two-sample Mendelian randomization study

F Zhi, J Ma, D Ji, J Bao, Q Li - Frontiers in Immunology, 2024 - frontiersin.org
Introduction Sepsis represents a critical medical condition that arises due to an imbalanced
host reaction to infection. Central to its pathophysiology are cytokines. However …

[HTML][HTML] Glatiramer acetate treatment effects on gene expression in monocytes of multiple sclerosis patients

M Thamilarasan, M Hecker, RH Goertsches… - Journal of …, 2013 - Springer
Background Glatiramer acetate (GA) is a mixture of synthetic peptides used in the treatment
of patients with relapsing-remitting multiple sclerosis (RRMS). The aim of this study was to …

[PDF][PDF] IL-27: 保持免疫平衡的重要因子

夏思源, 赵立青, 吴震洲… - Chinese Bulletin of Life …, 2010 - lifescience.sinh.ac.cn
由EBI-3 和p28 组成的IL-27 是IL-12 家族的新成员, 主要来源于树突状细胞(dendritic cells,
DCs) 的分泌. 当DCs 表面的Toll 样受体(Toll like receptor, TLR) 受到外界信号刺激的时候 …

[引用][C] 变应性鼻炎患者外周血中IL-27 和Treg 细胞的相关性分析

黄雪琨, 杨钦泰, 陈玉莲, 张富程, 张革化 - 中国组织化学与细胞化学杂志, 2013